老年科患者医院感染病原菌分布及耐药性分析

Distribution and drug resistance detection of pathogens isolated from senile patients

目的了解我院老年科医院感染患者病原菌分布特点及其对常用抗菌药物的耐药性。方法采用Vitek-2-Compact仪进行菌株鉴定及药敏试验,WHONET5.6软件进行统计分析。结果共检出病原菌766株,以下呼吸道痰标本检出率最高,占59.9%。病原菌检出前几位的依次是铜绿假单胞菌、大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌和鲍曼不动杆菌;大肠埃希菌和肺炎克雷伯菌中产超广谱β-酰胺酶(ESBLs)菌株的阳性率分别为70.4%和58.2%;非发酵菌中,铜绿假单胞菌对多种抗菌药物耐药率仍较低;而鲍曼不动杆菌呈多重耐药,亚胺培南耐药菌株分离率高达63.3%。金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)的检出率为50.3%。结论老年科主要的病原菌对临床常用抗菌药物耐药严重,临床应加强抗菌药物的合理使用和医院感染监控。

Objective To study the distribution and antibiotic resistance of pathogens isolated from the department of gerontology of our hospital. Methods The clinical isolates were identified with Vitek-2-Compact. The date was analyzed by WHONET5. 4 software. Results A total of 766 clinical strains were isolated, and 45. 8% of pathogens were found in samples from the sputum specimens. The main pathogens were P. aeruginosa, E. coli, S. aureus, K. pneumoniae and A. baumanii. 70. 4% of Escherichia coli and 58. 2% of K. pneumoniae produced extended spectrum β-lactamases （ ESBLs） . Among non-fermenters, Pseudomonas aeruginosa was sensitive to the most of anti-microbial agents. A. baumanii were multi-drug resistant and its resistance to carbapenem was up to 63. 3%. MRSA accounted for 50. 3% of S. aureus. Conclusion The pathogens isolated from senile patients are resistant to many an-timicrobial agents, and it is mandatory to take effective antibiotic policy and infection control measures.