1Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflam- mation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8 [ J]. Chest, 2001,119 : 1329 -36.
2Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clini- cal asthma phenotypes [ J ]. Am J Respir Crit Care Med,2008, 178:218 -224.
3Global Initiative for Asthma. Global Strategy for Asthma Manage- mentand Prevention 2009 (update). Henderson J, Granell R, Sterne J. The search for new asthmaphenotypes[ J]. Arch Dis Child, 2009, 94 : 333 - 336.
6Wenzel SE. Asthma : defining of the persistent adult phenotypes [ J ]. Lancet,2006,368 (9537): 804 - 813.
7Simpson JL, Scott R, Boyle M J, et al. Inflammatory subtypes in asthma: assessment and identification using induced sputum[ J]. Respirology, 2006, 11:54-61.
9Irwin RS, Baumann MH, Bolser DC, et al. Diagnosis and man- agement of cough executive summary: ACCP evidence-based clini- cal practice guidelines [ J ]. Chest, 2006, 129 ( 1 Suppl ) : S1 - $23.
10Gurski RR, da Rosa AR, do Valle E, et al. Extraesophageal man- ifestations of gastroesophageal reflux disease [ J ]. J Bras Pneumol, 2006,32(2) :150 - 160.
4Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss of asthma control. Am J Respir Cfit Care Med, 2000, 161:64-72.
5Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet, 2002,360:1715-1721.
6De la Fuente PT , Romagnoli M, Godard P, et al. Safety of inducing sputum in patients with asthma of varying severity. Am J Respir Crit Care Med, 1998,157 : 1127-1130.
7Ayararn L,Pizzichini MM, Cook RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J, 2006,27:483-494.
8Crimi E, SpaneveUo A, Neri M, et al.Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med, 1998, 157: 4-9.
9Pauwels RA, Lofdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) Internatianal Study Group. N Engl J Med, 1997,337 : 1405-1411.
10Bacci E,Cianchetti S, Bartoli M, et al. Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients. Chest, 2006, 129:565-572.
4Hsu JY, Wang CY, Cheng YW, et al. Optimal value of fractional exhaled nitric oxide in inhaled corticosteroid treatment for patients with chronic cough of unknown cause [ J ]. J Chin Med Assoc, 2013,76(1) :15 - 19.