摘要
目的探讨健脾化湿汤联合清肠栓对脾虚湿热型溃疡性结肠炎(UC)患者生存质量的影响。方法收集脾虚湿热型UC患者65例,随机分为治疗组32例,采用健脾化湿汤联合清肠栓治疗,对照组33例,采用健脾化湿汤治疗。治疗8周后,评价患者炎症性肠病生存质量问卷(IBDQ)、健康调查简表(SF-36)积分、肠镜计分和中医症状改善情况。结果在IBDQ总分、肠道症状(B)维度、一般健康状况(GH)维度评价方面,治疗组优于对照组(P<0.05);治疗组总有效率100%,对照组总有效率83.33%,2组间比较无统计学意义(P>0.05);单项症状脓血便、腹痛、里急后重症状比较,治疗组优于对照组(P<0.05)。肠道黏膜Baron评分,2组间比较无统计学意义(P>0.05)。结论健脾化湿汤联合清肠栓的内外合治法能有效改善脾虚湿热型溃疡性结肠炎患者的生存质量。
OBJECTIVE To study the effect of Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchangshuan on life quality of spleen-deficiency and dampness-heat type patients with ulcerative colitis(UC).METHODS 65 Patients were recruited with UC and belong to spleen-deficiency and dampness-heat type and were randomly divided into the treatment group and the control group,with 32 cases in treatment group(Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchangshuan),and 33 cases in control group(Jianpihuashi Decoction).The treatment lasted for 8weeks.The Inflammatory Bowel Disease Questionnaire(IBDQ),Short Form 36 Health Survey Questionnaire(SF 36),Enteroscopy Scores and Symptom Scores of Traditional Chinese Medicine were recorded before and after the treatment.RESULTS The record of treatment group had better reaction than the control group in IBDQ,bowel symptoms scale(B),and general health(GH)(P〈0.05).The effective rate in treatment group was 100%,which in the control group was 83.33%.And there was no statistical significance(P〉0.05)between two groups.Additionally,treatment group showed better reactions than control group in individual symptom,such as stool with blood and pus,abdominal pain and rectal tenesmus and there was statistical significance between two groups(P〈0.05).After the treatment,there was no statistical significance in Baron grade between two groups(P〉0.05).CONCLUSION Jianpihuashi Decoction combined with Chinese Herbal Medicine Qingchangshuan can better improve the life quality of patients with ulcerative colitis(UC)and belong to spleen-deficiency and dampness-heat type than Jianpihuashi Decoction only.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2015年第6期517-520,共4页
Journal of Nanjing University of Traditional Chinese Medicine
基金
国家自然科学基金(81403362)
国家中医临床研究基地龙医团队项目(LYTD-09)
上海自然科学基金(122R1432000)
2013年度上海大学生创新活动计划项目(教学115)
关键词
溃疡性结肠炎
生存质量
健脾化湿汤
清肠栓
ulcerative colitis
life quality
Jianpihuashi Decoction
Chinese Herbal Medicine Qingchangshuan