三叉神经痛患者局部一致性研究

Regional homogeneity changes in patients with trigeminal neuralgia

目的探讨三叉神经痛（TN）患者与正常对照者在静息状态下全脑范围内的局部自发活动的差异。方法收集30例TN患者（均来自广东省第二人民医院神经外科或神经内科，收治时间为自2012年7月至2013年12月）和20例正常对照者（同期招募的性别比例、年龄、受教育年限与患者相匹配的健康志愿者）的静息态功能磁共振成像数据，结合局部一致性分析方法，以两独立样本t检验比较2组被试局部一致性值的差异。结果与正常对照者相比，TN患者多个脑区存在异常自发活动，其中左侧颞中回、左侧海马旁回的局部一致性值降低，双侧丘脑及左侧顶叶的局部一致性值增高。结论局部一致性分析从功能分化的角度揭示了TN患者存在的脑功能活动异常，这些脑区基本属于疼痛的感知和处理区域。这些白发活动的异常将有助于对TN发生机制的理解。

Objective To explore the regional spontaneous activity changes in patients with trigeminal neuralgia （TN） using resting-state functional MRI. Methods Resting-state functional MRI datasets were acquired from 30 patients with TN, admitted to our hospital from July 2012 to December 2013, and 20 age, gender and education level matched healthy controls. The regional homogeneity （ReHo） method and independent-sample t-test were used to compare the brain activity differences between these two groups. Results Decreased ReHo values in the left temporal, left para-hippocampal, as well as increased ReHo values in the bilateral thalamus and left parietal lobe were noted in TN patients as compared with those in the healthy controls. Conclusions The abnormal spontaneous activity exists in TN patients, and these abnormal regions are mainly associated with the perception and processing of pain. In addition, spontaneous activity alternation might promote the exploration of mechanism of TN.