不同首发年龄抑郁发作患者临床特征分析

Clinical features of depressive episode patients with different first-episode ages

目的探讨不同首发年龄抑郁发作患者的人口学资料和临床特征。方法采用中位数切割法将632例成年抑郁发作患者分成早发组323例和晚发组309例，比较两组人口学资料及临床特征的差异性。结果早发组患者男性、未婚者居多，家庭支持相对较差；晚发组患者女性、已婚者居多，家庭月收入相对更高（P〈0．01）。晚发组罹患躯体疾病率、汉密顿抑郁量表总分及焦虑躯体化、睡眠障碍因子分和临床总体印象一疾病严重程度分量表总分均显著高于早发组（P〈0．01）。结论早发与晚发型抑郁发作患者人口学资料和临床特征存在差异性，晚发型患者共患躯体病发生率高，临床症状及抑郁程度更严重，更多表现为焦虑躯体化症状及睡眠障碍。

Objective To explore demographic data and clinical features of depressive episode patients with different first-episode ages. Methods A total of 632 depressive episode adults were assigned to early- onset （n=323） and late-onset （n=309） group using median method and group differences of demographic data and clinical features compared. Results Most were male and unmarried and their family supports poor relatively in early-onset group; most were female and married and their family monthly incomes high- er relatively in late-onset group （P〈0.01）. Morbidity rate of somatic disease, the total, anxiety/somati- zation and sleep disorder score of the HAMD as well as the total score of CGI-S were significantly higher in late-onset than in early-onset group （P〈0.01）. Conclusion There are differences in demographic data and clinical features between early-onset and late-onset depressive episode patients, in late-onset patients the incidence of comorbid somatic diseases is higher, clinical symptoms and depressive degrees are severer and mainly anxiety/somatization symptoms and sleep disorders.