益肺汤联合吉非替尼治疗肺癌脑转移头痛50例临床研究

Clinical Research on of Gefitinib and Yifei Decotion in the Treatment of Brain Metastases of Lung Cancer

目的:观察益肺汤联合吉非替尼治疗肺癌脑转移头痛患者的临床效果。方法:将98例肺癌转移头痛患者随机分为研究组(n=50)与对照组(n=48),研究组患者采用益肺汤联合吉非替尼结合常规放疗治疗,对照组患者采用紫杉醇联合常规放疗治疗,观察比较两组患者的临床疗效。结果:经过治疗,研究组患者治疗总有效率为54.00%,明显高于对照组的33.33%,差异具有统计学意义(P<0.05);研究组患者呕吐、恶心、腹泻、白细胞下降、皮疹、转氨酶升高等不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05);研究组患者总生存期为(14.67±2.74)个月,明显高于对照组(7.69±2.08)个月,差异具有统计学意义(P<0.05)。结论:益肺汤联合吉非替尼治疗肺癌转移头痛效果显著,可显著减少患者肿瘤病灶,延长其生存期,降低不良反应发生率,有效提高生存质量,值得临床推广应用。

Objective：To explore the clinical effect of the treatment of lung cancer patients with brain metastasis from lung cancer with the combination of Gefitinib and lung decoction. Methods：98 patients were randomly assigned for the study group of 50 cases, 48 cases in the control group, patients in study group were given Yifei decoction combined with gefitinib imatinib and conventional radiotherapy treatment, the control group of patients given paclitaxel combined with conventional radiotherapy treatment, evaluation the clinical efficacy of two groups of patients, aesu｜ts： after treatment, observation group in the treatment of tumor patients with to- tal efficiency and overall survival was significantly higher than that of the control group, incidence of adverse reactions was signifi cantly lower than that of the control group, group significant difference （P^O. 05）, with statistical significance. Conclusion： yifei lung soup decoction combined with gefitinib imatinib treatment of lung cancer metastasis headache patients can significantly reduce the number of tumor, prolong survival and reduce the incidence of systemic adverse reactions, improve the life quality of patients can be spread and applied in the clinical range.