重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死的中文文献 Meta 分析

Meta-analysis of Chinese literature on the treatment of acute cerebral infarction by intravenous thromboly-sis with recombinant tissue -type plasminogen activator

目的：评价采用重组组织型纤溶酶原激活剂（rt－PA）静脉溶栓治疗急性脑梗死（ACI）的临床疗效及安全性。方法检索中国知网（CNKI）、中国生物医学文献数据库（CBMdise）、万方数据库从建库至2015年3月的参考文献，筛选所有使用rt－PA静脉溶栓治疗ACI的随机对照试验（RCT ）研究，由两名评价员独立检索和评价文献质量，采用RevMan5．2软件进行M eta分析。结果共纳入8篇RCT研究，试验组248例，对照组298例。采用rt－PA静脉溶栓治疗的患者神经功能缺损（NIHSS）评分、日常生活活动能力（ADL ）评分改善显著，出血的风险增加，两组间差异均有统计学意义（ P ＜0.05）。结论中国现有数据库文献显示，rt－PA静脉溶栓治疗可显著改善脑梗死后神经功能和日常生活能力，但出血的风险增加。

Objective To evaluate the clinical efficacy and safety of recombinant tissue -type plas‐minogen activator （rt-PA） in the treatment of acute cerebral infarction （ACI） .Methods The CNKI , CBMdise and Wanfang Database （all till Mar ,2015） were retrieved by computer to collect randomized controlled trials（RCTs） of rt -PA in the treatment of ACI .Two reviewers independently retrieved and evaluated literature quality .The RevMan 5 .2 software was used for Meta -analysis .Results Eight RCTs were included in the study ,248 cases in the treatment group （using rt-PA） and 298 cases in the control group （using conventional therapy） .Meta-analysis showed that there were significant difference in the NIHSS score ,ADL score and risk of bleeding between the treatment group and control group （P 〈 0 .05） .Conclusions The Meta-analysis results from databases indicate that rt -PA can improve the neurological function ,the activities of daily living and increase the risk of bleeding in ACI .