空间标准化对帕金森病脑代谢网络应用的影响

Effect of Spatial Normalization in Parkinson's Disease-related Pattern Expression

目的:在建立国人帕金森病患者(PD)的疾病相关脑代谢网络模式(PDRP)的基础上,探讨临床应用中空间标准化方法对PDRP表达值的影响。方法:对53例PD患者和22例健康对照者分别行静息状态下18F-FDG PET脑成像,分别利用SPM99、SPM2、SPM5、SPM8进行对上述75例研究对象进行空间标准化。并以华山医院PET中心建立的PDRP为参照标准,对上述标准化的PET图像进行基于体素的脑地形剖面分级(TPR)运算,获得相应的PDRP表达值。结果:四个版本SPM所得的PDRP表达值均无显著差异(PD组:F3,208=0.001,P=1.000;对照组:F3,84=0.000,P=1.000),且PD患者PDRP值区分于正常对照者(t>9.875,P<0.0001;Student’s t检验),四个版本SPM所得PDRP值互为显著正相关(PD组:r>0.999,P<0.0001;对照组:r>0.999,P<0.0001),且均与UPDRS正相关(r>0.670,P<0.0001)。结论:在PD患者与正常对照中,不同SPM版本空间标准化对PDRP表达值均无影响,因此PDRP是一种稳定、可靠的影像学标志物,可以运用于多中心研究。

Purpose： The effect of spatial normalization to Parkinson＇s disease related pattern（PDRP） expression should be verified to be widely used in the clinic. Methods： The 18F-FDG PET images of 53 Parkinson＇s disease（PD） patients and 22 heath control subjects（HC） were normalized by SPM99, SPM2, SPM5 and SPM8, separately. Based on the PDRP from PET center, Huashan Hospital, the PDRP expressions of different algorithms were calculated by SSM/PCA software. Results： There was no difference of PDRP expression between four SPM versions（PD group： F3,208=0.001,P=1.000;HC group： F3,84=0.000,P=1.000）. The PDRP expression of PD group was significantly higher than that of HC group（t〉9.875,P〈0.0001; Student＇s t-test）. By Pearson correlation analysis, the PDRP expression of four SPM versions had significantly positive correlation with each other both in PD and HC（PD： r〉0.999, P〈0.0001; HC： r〉0.999, P〈0.0001）. In addition, the PDRP expression had significantly positive correlation with PD patients＇ UPDRS motor function value（r〉0.670, P〈0.0001）. Conclusion： The PDRP expression from different SPM normalization versions was with no significant difference. Additionally, the reconstruction algorithm can＇t affect the application of PDRP in diagnosis or assessment of PD, which was important information for domestic multi-center researches.