原发性肝癌患者细胞免疫功能与中医正气学说的关系研究

Relationship Study Between Primary Liver Cancer Cell Immune Function and Qi Theory of Traditional Chinese Medicine

目的:检测慢性乙型肝炎、活动性肝硬化和原发性肝癌患者外周血T淋巴细胞亚群中CD3+、CD4+、CD8+细胞水平及CD4+/CD8+比值,研究细胞免疫状态在三类患者中的变化,探讨现代医学中细胞免疫功能与祖国医学中正气学说的联系。方法:采用流式细胞仪检测慢性肝炎、活动性肝硬化和原发性肝癌患者外周血中CD3+、CD4+、CD8+T淋巴细胞的数量(单位:/ul)及CD4+/CD8+比值。结果:HCC患者外周血中CD3+、CD4+、CD8+细胞数均低于慢性肝炎和活动性肝硬化患者。结论:慢性乙型肝炎、活动性肝硬化患者外周血T淋巴细胞的改变,机体细胞免疫功能降低,可以导致肝癌细胞的发生。

Objective： Monitoring of peripheral blood T lymphocyte subsets of CD3＋,CD4＋and CD8＋cells in patients with chronic hepatitis B,active cirrhosis and primary liver cancer patients,studying three aspects of population dynamics in immune cells,and to explore the cellular immune function in modern medicine and traditional Chinese medicine theory of contact in righteousness. Methods： Flow cytometry chronic hepatitis,cirrhosis and primary liver cancer activity in patients with CD3＋,CD4＋,CD8＋T lymphocyte count（ Unit： / μl） change. Results： CD3＋,CD4＋,CD8＋cells count of patients with primary liver cancer were lower than chronic hepatitis and active cirrhosis. Conclusion： The change of peripheral blood T lymphocytes in patients with Chronic B hepatitis and active cirrhosis,the reduction of the immune function,may lead to the occurrence of liver cancer cells.