HIV感染者HAART中LEP、HCY的变化及临床意义

Clinical Significance of Changes of LEP and HCY Levels in Serum of HIV-infected Patients Receiving Highly Active Antiretroviral Therapy

通过检测HIV感染者在高效抗逆转录病毒治疗(highly active anti-retroviral therapy,HAART)过程中心血管疾病(cardiovascular disease,CVD)的标志物同型半胱氨酸(homocysteine,HCY)和瘦素(leptin,LEP)的含量,判断其在HIV感染人群中对CVD的预防作用。采用酶联免疫吸附实验(ELISA)检测桂林市第三人民医院62例HIV感染者和30名健康对照组血清中LEP和HCY水平,结果显示,HIV感染治疗组血清HCY的水平明显高于未治疗组与正常对照组,差异具有统计学意义(P<0.01),血清LEP在3组中无明显变化(P>0.05),血清HCY与CD4+T淋巴细胞计数及TG呈正相关作用(P<0.01)。可见,在HIV感染者HAART过程中,动态地检测病人血清HCY水平有助于HIV感染者并发CVD的早期预防,为HIV感染人群并发CVD提供早期预防依据。

The content of Leptin （LEP） and homocysteine （HCY） of cardiovascular diseases （CVD）markers in HIV infected patients was detected in Highly active antiretroviral therapy （HAART） processand the effect on prevention of CVD in HIV infected patients was determined to provide a basis for earlyprevention in HIV infection complicated with CVD. Methods： Serum samples obtained from 30 healthysubjects and 62 HIV infected patients（28 treatment naive and 34 treatment experienced patients） wereanalyzed by enzyme-linked immunosorbent assay （ELISA） to determine the HCY and LEP contents.TheResults show that the level of serum HCY in HIV infected treatment group was obviously higher thanthat of untreated group and normal control group （P〈0.01）.There was no marked difference of the LEPlevel between the three controls（P〈0.05）. Serum HCY and CD4＋T lymphocyte count, treatment timeand TG were positively correlated （P〈0.01）. Dynamically detecting the level of HCY and LEP may bebeneficial to the early prevention of HIV infection complicated with CVD.