茚类衍生物的合成研究进展

Research Progress on Synthesis of Indene Derivatives

茚类衍生物是自然界中普遍存在的一类化合物,其不仅具有较好的药理活性,在材料化学方面也有重要的应用。近年来,合成茚类衍生物的报道有很多,但其合成过程总会受到某些反应条件的限制,这对其工业化生产过程形成了很大的阻力。因此,发展新型高效合成茚类衍生物的方法已成为有机合成的热点领域。茚类衍生物的合成主要有两种方法:分子内环化反应与分子间环加成反应。文章将对这两种合成方法进行简单的介绍。

The indene derivatives is a class of compounds which exists widely in natural world,it not only has good pharmacological activities,but also has important applications in materials chemistry. In recent years,there are a lot of synthesis of indene derivatives are reported,however,the process of synthesis is limited by some reaction conditions,which is a great resistance to the process of industrialization. Thus,the development of new efficient synthesis of indene derivatives has become a hot topic in the field of organic synthesis. There are two typical approaches employed to form indene derivatives：intramolecular cyclization and intermolecular cyclization. These two methods of synthesis were briefly introduced.