摘要
目的探讨2型糖尿病(T2DM)和代谢综合征(MS)与血清游离脂肪酸(FFA)、同型半胱氨酸(Hcy)的关系。方法测定129例T2DM患者,其中合并有MS的患者83例(T2DM合并MS组),无MS的患者46例(单纯T2DM组),比较两组患者的腰围、血压、FFA、Hcy、血脂等指标,并分析MS患者FFA、Hcy与其他指标的相关性。结果 T2DM合并MS组腰围、SBP、TG、FFA水平高于单纯T2DM组,Apo-AI水平则低于单纯T2DM组,差异均有统计学意义(P<0.05)。Hcy水平与LDL-C水平存在正相关性,FFA水平与TC、TG、GLU水平存在正相关性。结论 T2DM合并MS患者高FFA血症情况比单纯T2DM严重,并且FFA水平可能和血清TC、TG、GLU水平相关;T2DM合并MS患者血清Hcy水平与单纯T2DM没有差异性,血清Hcy水平可能与LDL-C水平有关。
Objective To explore the relationship between free fatty acid（FFA）and homocysteine（Hcy）with type 2 diabetes mellitus（T2DM）and metabolic syndrome（MS）.Methods 129 T2DM patients,including 83 cases of MS and 46 cases of non-MS.The indicators of waist circumference,blood pressure,FFA,Hcy and blood lipid were compared between the two groups and the correlation between FFA and Hcy with other indicators was analyzed.Results The waist circumference,SBP,TG and FFA in the T2DM complicating MS group were higher than those in the simple T2DM group,while the Apo-AI level was lower than that in the simple T2DM group,the differences were statistical significant（P〈0.05）.Serum Hcy and LDL-C had positive correlation.Serum FFA was positively correlated with TC,TG and GLU levels.Conclusion Serum FFA level in the patients with T2DM complicating MS is higher than that with simple T2DM and the serum FFA level might be correlated with TC,TG and GLU levels;serum Hcy level has no difference between the patients with T2DM complicating MS and the patients with simple T2DM,serum Hcy level may be related with LDL-C level.
出处
《检验医学与临床》
CAS
2015年第21期3131-3132,3136,共3页
Laboratory Medicine and Clinic
基金
国家高技术研究发展计划(863课题)(2011AA02A111)
