摘要
目的探讨肥胖型和非肥胖型多囊卵巢综合征(PCOS)患者的内分泌特征是否相同。方法选择就诊的未经过药物治疗的PCOS患者211例,分为肥胖组和非肥胖组,分别检测其基础血清总睾酮(TT)、硫酸脱氢表雄酮(DHEAS)、性激素结合球蛋白(SHBG)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(PO)及催乳素(PRL)水平,并对其进行统计分析。结果肥胖组PCOS患者的SHBG、LH、E2和PO明显低于非肥胖组,差异有统计学意义(P<0.05)。PCOS患者肥胖与TT、FSH及E2绝对正相关,与SHBG、LH及PO绝对负相关,差异有统计学意义(P<0.05)。结论肥胖型和非肥胖型PCOS患者的基础内分泌指标间存在差异,这对于进一步了解PCOS的发病机制及异质性具有重要意义。
Objective To investigate whether having the same endocrine characteristics in non-obese and obese women with polycystic ovary syndrome（PCOS）.Methods 211 untreated women with PCOS were selected and divided into the obese group and the non-obese group.The basal levels of serum total testosterone（TT）,dehydroepiandrosterone sulfate（DHEAS）,sex hormone binding globulin（SHBG）,follicle stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2）,progesterone（PO）and prolactin（PRL）were measured and the results were analyzed statistically.Results The basal SHBG,LH,E2 and PO levels in the PCOS patients of the obese group were significantly lower than those of the non-obese group,the difference was statistically significant（P〈0.05）.Obese was absolutely positively correlated with the TT,FSH and E2 levels in the PCOS patients,but absolutely inversely correlated with the SHBG,LH and PO levels（P〈0.05）.Conclusion The difference of basal endocrine indicators exist between non-obese and obese women with PCOS,which has an important significance for further understanding the pathogenesis and heterogeneity of PCOS.
出处
《检验医学与临床》
CAS
2015年第21期3172-3174,共3页
Laboratory Medicine and Clinic
基金
首都医科大学附属北京妇产医院院内课题(2013-13)
