老年糖尿病合并肺结核患者超敏C反应蛋白水平的动态变化

DYNAMIC CHANGE OF THE PERSENSITIVE C-REACTIVE PROTEIN LEVEL IN ELDERLY DIABETES COMPLICATED WITH PULMONARY TUBERCULOSIS

目的观察老年糖尿病合并肺结核患者血清超敏C反应蛋白(persensitive C_reactive protein,hsCRP)水平,探讨hs-CRP在老年糖尿病合并肺结核患者治疗过程中的动态变化。方法选取2013年5月—2015年8月该院收治的单纯老年肺结核患者40例,非老年糖尿病合并肺结核者40例,老年糖尿病合并肺结核患者40例,给予2HRZE/4HR抗结核治疗,分别于治疗前、治疗后1、3、6个月末检测血清hsCRP,分析各组不同时段hs-CRP水平变化。结果所有老年糖尿病肺结核患者hs-CRP含量明显高于非老年糖尿病合并肺结核患者(P<0.01);糖尿病合并肺结核患者高于单纯老年肺结核患者,随着肺结核治疗时间延长hs-CRP含量逐渐减低,P均<0.01。结论认为老年糖尿病合并肺结核患者血清hsCRP含量升高,经过抗结核治疗随着时间延长下降,可作为临床结核治疗效果监测指标。

Objective To observe the level of serum hypersensitive c-reactive protein in elderly diabetic tuberculosis patients,and to discuss the dynamic changes of serum hypersensitive c-reactive protein in the process of pulmonary tuberculosis patients.Methods Forty cases of the elderly patients with tuberculosis was in group A,forty cases of elderly diabetes complicated with pulmonary tuberculosis was in group B,and forty cases of non elderly diabetes complicated with pulmonary tuberculosis in group C.All tuberculosis patients in group A and group B were treated with2HRZE/4HR,and serum hs-CRP was detected before treatment,respectively 1 months,3 months and 6 months after treatment,and then the changes of hs-CRP levels in different periods were analyzed.Results The hs-CRP content of group B was significantly higher than that of group C（P 〈0.01）,and it was also higher than those of group A.Hs-CRP content decreased gradually with the treatment time of pulmonary tuberculosis.Conclusions The serum hs-CRP level in elderly patients with diabetes mellitus complicated with pulmonary tuberculosis is higher.It is declined with the time after the antituberculosis treatment,and it can be used as a monitoring indicator on clinical tuberculosis treatment effect.