舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合沐舒坦治疗慢性阻塞性肺疾病的临床疗效评价

EVALUATION OF CLINICAL EFFICACY OF SERETIDE COMBINED WITH TIOTROPIUM BROMIDE POWDER FOR INHALATION COMPARED WITH SERETIDE COMBINED WITH MUCOSOLVAN IN THE TREATMENT OF COPD

目的观察舒利迭联合噻托溴铵粉吸入剂对比舒利迭联合沐舒坦治疗慢性阻塞性肺疾病（COPD）的临床疗效,探讨其治疗COPD的安全性及有效性,为临床治疗方法提供参考依据。方法选取该院就诊的210例COPD患者随机分为舒利迭组、舒利迭联合噻托溴铵粉吸入剂治疗组及舒利迭联合沐舒坦治疗组,每组各70例。根据治疗后PO2、PCO2及肺功能、体征评分等为指标对患者恢复程度进行评估。结果治疗后,三组治疗结果均有显著改善,其中舒利迭组在用药3个月内效果显著,舒利迭联合沐舒坦在用药3-6个月内效果显著,舒利迭联合噻托溴铵粉吸入剂在3-12个月效果显著。结论舒利迭联合噻托溴铵粉吸入剂在治疗COPD的远期临床疗效好,舒利迭联合沐舒坦在治疗COPD过程中展现的短期疗效显著,此结果可为后期临床中用药提供依据。

Objective To observe the Seretide combined with Thiazide supporting clinical curative effect of Bromide powder inhalation compared Seretide combined with Mucosolvan in the treatment of COPD,and to investigate the therapeutic efficacy and safety on chronic obstructive pulmonary disease（COPD）,so as to provide reference for clinical treatment.Methods A total of 210 cases of COPD patients treated in author＇s hospital,were randomly divided into Seretide group and Seretide combined with Thiazide supporting bromide powder for inhalation in the treatment group and Seretide combined with Mucosolvan treatment group（70 cases in each group.And then PO2,PCO2 and pulmonary function,signs score and other indicators were use to assess the degree of recovery of patients.Results The treatment results of three groups were significantly improved,the Seretide group within 3 months of treatment effect was remarkable,Seretide combined with Mucosolvan in3-6 months of treatment effect was remarkable,Seretide combined with Thiazide supporting bromide inhalation powder had significant effect in the 3-12 months.ConclusionSeretide combined with Thiazide supporting bromide inhalation powder shows a better long-term clinical efficacy in treatment of patients with COPD,the short-term curative effect of Seretide plus Mucosolvan is the best for COPD.