摘要
药物性肝损伤是指药物或其代谢产物引起的肝功能异常或肝脏对药物及代谢产物的超敏反应所致的疾病,分为本质性肝损伤和特异性肝损伤两大类,与细胞色素P450(CYP450)酶系统相关的药物性肝损伤是特异性肝损伤发生最主要的机制,药物或其代谢产物的直接损伤、过敏反应、免疫系统激活和氧化应激造成线粒体损伤也是药物性肝损伤发生的主要因素之一。
Drag induced liver injury refers to liver function abnormalities caused by drugs or their metabolites or liver disease caused by hypersensitivity to the drug and their metabolites. It can be divided into the essence of liver injury and liver specific injury, mechanism of specific liver injury is the most important with cytochrome P450 （CYP450） of hepatic injury related enzyme system, direct injury of drugs and their metabolites, allergic reactions, immune system activation, mitochondrial damage caused by oxidative stress, all of these are one of the main causes of dru^-induced liver iniurv.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第19期1-3,共3页
Chinese Journal of Clinicians(Electronic Edition)
关键词
药物性肝损伤
机制
Drug-induced liver injury
Mechanism
