可溶性血管内皮生长因子受体1的研究进展

Research progress in soluble vascular endothelial growth factor receptor-1

可溶性血管内皮生长因子受体1(s VEGFR-1)是近年来发现的被认为在抗血管生成中起重要作用的因子,它是一种具有酪氨酸激酶活性的糖蛋白,在血液循环中通过拮抗VEGF的生物功能发挥作用。近年来的研究表明,其可以参与多种生理和病理状况中并在临床疾病的诊断及治疗中,受到越来越多的关注。现对s VEGFR-1的分子生物学、病理生理作用、分子作用机制以及在临床上的应用等方面的研究作相关阐述。

Soluble vascular endothelial growth factor receptor 1 （sVEGFR-1） which is discovered in recent years is thought to play an important role in the anti-angiogenesis. It is a kind of tyrosine kinase activity glycoprotein, plays a role by antagonizing VEGF biological function in the blood circulation. Recent studies show that it can participate in a variety of physiological and pathological conditions and attract more and more attention in the diagnosis and treatment of clinical disease. In this review, we elaborated the molecular biology, pathophysiology role, molecular mechanism, as well as the clinical aoolication of the sVEGFR- 1.