高通量血透治疗终末期肾病的临床观察

Clinical Observation of High Flux Hemodialysis in the Treatment of End-stage Renal Disease

目的:研究高通量血透治疗终末期肾病的临床效果。方法:选取2010年7月-2012年6月本院收治的终末期肾病患者50例作为研究对象,首先予以常规血透,作为常规阶段,1年后予以高通量血透治疗,疗程为1年,为观察阶段,比较两阶段内患者的相关指标。结果:经高通量血透治疗后,患者精神和体力好转;治疗后,观察阶段与对照阶段的血磷、β2-微球蛋白均显著低于治疗前水平,血红蛋白含量则高于治疗前,比较差异具有统计学意义(P<0.05);治疗后观察阶段与对照阶段的PTH均低于治疗前,且观察阶段的PTH清除率较对照阶段有显著升高,比较差异具有统计学意义(t=13.29、字2=9.67;P<0.05);观察阶段的降压药使用频率以及并发症率均明显低于对照组(字2=8.57、11.38,P<0.05)。结论:应用高通量血透治疗终末期肾病的疗效确切,有利于各项临床体征的改善与病情缓解,也能避免治疗过程中的并发症风险,较常规血透更为安全可靠。

Objective：To study the clinical effect of high flux hemodialysis in the treatment of end-stage renal disease. Method：50 patients with end-stage renal disease treated in our hospital from July 2010 to June 2012 were treated as the research objects,and the routine blood was first given as the conventional phase, and the 1 year after the treatment, high flux hemodialysis was given for 1 year. The correlation indexes of patients in the two stage were compared.Result：After treatment with high flux hemodialysis, spirit and physical strength improved.After treatment,the serum phosphorus and β2-microspheres were significantly lower than those in the control stage.The differences were statistically significant（P〈0.05）.The PTH clearance rate of the observation group was significantly higher than that of control stage（t=13.29, χ2=9.67,P〈0.05）.The frequency of use and complication rate were significantly lower than those in control stage（ χ2=8.57,11.38,P〈0.05）.Conclusion：The application of high flux hemodialysis in treatment of end stage renal disease is effective,it is beneficial to improve the clinical signs and the remission of the disease,but also to avoid the complications of the treatment process,the more safe and reliable than conventional hemodialysis.