布地奈德联合沙丁胺醇雾化对喘息性支气管炎儿童肺功能的影响

Effect of Budesonide Combined with Salbutamol on Lung Function of Children with Asthmatic Bronchitis

目的探讨布地奈德联合沙丁胺醇雾化对喘息性支气管炎儿童肺功能的影响。方法收集2013年12月~2014年12月接受治疗的喘息性支气管炎患儿100例,按照随机数字表格法分为治疗组与对照组,各50例,其中对照组给予沙丁胺醇雾化治疗;观察组在沙丁胺醇治疗基础上给予布地奈德雾化治疗,比较两组患儿治疗前后肺功能的变化。结果治疗组患儿治疗后临床有效率为94.00%,高于对照组患儿74.00%（χ^2=7.15,P〈0.05）。治疗组患儿的临床相关症状、体征完全消失时间及住院时间均明显优于对照组患儿（t=5.15、6.03、7.31、5.80、5.68,P均〈0.05）。治疗组患儿治疗后的肺功能各项指标明显优于对照组患儿（t=12.10、9.60、8.49、11.03、13.43,P均〈0.05）。结论布地奈德联合沙丁胺醇雾化治疗儿童喘息性支气管炎可提高临床疗效,改善症状及体征,有效改善肺功能,值得临床推广应用。

OBJECTIVE To study the effect of budesonide combined with salbutamol on lung function of children with asthmatic bronchitis. METHODS 100 cases of children with asthmatic bronchitis were collected in December 2013 to December 2014 for treatment,they were divided into treatment group and control group with 50 cases in each group according to the random number table methods,the control group received salbutamol for treatment while the observation group were given budesonide atomization treatment on basis of salbutamol,the changes of pulmonary function of the two group before and after treatment were compared. RESULTS The clinical effective rate of the treatment group after treatment was 94%,higher than 74% in the control group,there was significant difference between two groups（ χ^2= 7. 15,P〈0. 05）. The clinical symptoms,signs disappeared time and hospitalization time of the treatment group after treatment was better than the control group,with significant differences between the two groups（ t = 5. 15,6. 03,7. 31,5. 80,5. 68,P〈0. 05）. The pulmonary function index in the treatment group after treatment was significantly better than the control group,there was significant difference between two groups（ t =12. 10,9. 60,8. 49,11. 03,13. 43,P〈0. 05）. CONCLUSION Budesonide combined with salbutamol may improve the curative effect,symptoms and signs and lung function in treatment of children with asthmatic bronchitis,which is worthy of clinical application.