索利那新对压力性尿失禁患者性功能的影响

The Effect of Solifenacin on Sexual Function in Women with Stress Urinary Incontinence

目的研究索利那新对女性压力性尿失禁（SUI）患者性功能的影响及相关因素。方法 2013年12月~2014年5月接受索利那新治疗的94例患者纳入研究,采用盆腔器官脱垂-尿失禁患者性功能（PISQ-12）问卷对患者进行随访评分。结果 81例（86.1%）患者回答了PISQ-12问卷,服药前前PISQ总评分为（83.9±10.6）min,服药后为（84.6±15.3）min,差异无统计学意义（P〉0.05）。但服药前后情感因素评分为（27.1±10.7）min和（30.5±6.7）min,两者比较具有显著性差异（P〈0.05）。溢尿组性生活改善率为67.5%（25/37）,无溢尿组性生活改善率为22.7%（10/44）,两者比较,差异有统计学意义（P〈0.01）。重度组PISQ总评分升高率为67.5%（27/35）,中度组PISQ总评分升高率为32.6%（15/46）,两者比较,差异有统计学意义（P〈0.05）。结论索利那新对性生活中不自主溢尿者和尿失禁重度患者,服药后症状缓解,可显著提高性生活质量。

OBJECTIVE To evaluate postoperative effects of solifenacin on sexual function of female patients with genuine stress urinary incontinence. METHODS 94 sexually active patients who underwent TVT-O procedure between December 2013 and May 2014 in our urological center were included in this study. During the follow-up period,they were evaluated their sexual function with the Pelvic Organ Prolapse / Incontinence Sexual Questionnaire-12（ PISQ-12）. RESULTS 81 patients（ 86. 1%） completed the questionnaire. The total average scores of PISQ-12were（ 85. 3 ± 10. 6） min and（ 84. 6 ± 16. 5） min before and after treat,respectively,and there was no significant difference（ P〉0. 05）; however,the behavioral emotional domain scores increased significantly from（ 27. 1 ± 10. 7）min to（ 30. 5 ± 6. 7） min（ P〈0. 05）; The sexual function improvement rats were 67. 5%（ 37 /49） and 22. 7%（ 9 /35） in patients with and without urine leakage during sexual intercourse,respectively. Similarly,most of patients with serious SUI could get sexual function improvement. CONCLUSION The patients with involuntary urine leakage during sexual intercourse or serious symptom may improve their sexual function due to the leakage alleviation.