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帕金森病相关基因动物模型研究进展 被引量:2

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摘要 帕金森病是第二大常见的神经退行性疾病,其主要病理机制是黑质多巴胺(dopamine)能神经元进行性变性坏死和路易小体(Lewybody)的形成,造成多巴胺生成障碍,从而出现一系列运动相关性症状。目前没有可靠的治疗方法能够抑制甚至减少疾病的进程,因此制作帕金森病相关动物模型对疾病病理机制的认识、探索新的治疗策略具有重大意义。
出处 《中华神经科杂志》 CAS CSCD 北大核心 2015年第11期1026-1029,共4页 Chinese Journal of Neurology
基金 国家自然科学基金资助项目(81200870,81430023,81371405)
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