环氧化酶-2在子宫内膜癌中的表达及意义

Expressions and significances of Cox-2,estrogen receptor and progesterone receptor in endometrial cancer

目的检测Cox-2在子宫内膜癌(EC)组织中的表达,探讨Cox-2在子宫内膜癌的发生、发展中的作用及相互关系。方法采用免疫组织化学染色,检测Cox-2在正常子宫内膜、不典型增生内膜、子宫内膜癌中的表达,分析Cox-2与子宫内膜癌临床病理特征的关系。结果⑴Cox-2在正常子宫内膜、不典型增生内膜、子宫内膜癌组织中的阳性表达差异有统计学意义;⑵Cox-2在不同病理分级及不同FIGO分期中的阳性表达率比较中,P>0.05,差异无统计学意义;Cox-2阳性表达率在不同肌层浸润深度比较,P<0.05,差异有统计学意义;Cox-2在有无淋巴结转移组比较,P<0.05,差异有统计学意义。结论 Cox-2高表达与子宫内膜癌有密切关系,Cox-2参与了子宫内膜癌的发生、发展过程。Cox-2的过度表达可促进肿瘤的侵袭和转移。

Objective To investigate the role of Cox-2 in the occurrence and development of endometrial carcinoma（EC）,this study aimed to examine the expression of Cox-2 in the EC tissue. Methods We examined the expression of Cox-2 in the tissues of normal endometrium,atypical hyperplasia of endometrium and EC using immunohistochemistry staining. The relationship of Cox-2 and clinical pathological features w analyzed. Results ⑴The difference of the positive expression of Cox-2 was statistically significant among the tissues of normal endometrium,atypical hyperplasia of endometrium and EC. ⑵There was no statistical significance difference（P〈0.05） in the positive expression rate of Cox-2 in the pathological classification and FIGO staging. Whereas,there was statistical significance difference（P〈0.05） in the positive expression rate of Cox-2 in the different muscular infiltration depth. There was also statistically significant difference（P〈0.05） in the positive expression rate of Cox-2 compared withpresence or absence of lymph node metastasis. Conclusion There was close relationship between overexpression of Cox-2 and EC. Our results indicate that Cox-2 may be involved the occurrence and development of EC and that overexpression of Cox-2 may promote tumor infiltration and metastasis.