摘要
目的实验研究枇杷木白皮对化疗药顺铂引起神经递质的改变的影响,探讨其防治顺铂引起的恶心呕吐作用的可能机制。方法通过小鼠尾静脉注射顺铂建立小鼠呕吐模型,将小鼠随机分为6组:空白对照组、造模组、枇杷木白皮大、中、小剂量组、甲氧氯普胺组。各组均灌胃给药2周,通过5-羟色胺(5-HT)、多巴胺(DA)的检测试剂盒测定小鼠脑组织内5-HT及DA的含量。结果枇杷木白皮大、中、小剂量组小鼠脑组织5-HT、DA含量明显低于造模组(P<0.01),同时也低于甲氧氯普胺组(P<0.05)。结论枇杷木白皮对顺铂引起小鼠恶心呕吐的作用机制可能是通过抑制5-HT、DA的分泌或是提高其降解而实现的。
Objective To study on the effect of Loquat Bark to the neurotransmitters changed by Cisplatin,investigate the mechanism of Loquat bark to stop Cisplatin-induced-vomit. Methods Establishing emetic model by injected Cisplatin from tail vein. The mice were randomly divided into 6 groups：blank control group,model group,Loquat Bark（in high-,mid-,and low-dose）groups,Metoclopramide group. Every group was taked gavage for 2 weeks. 5-HT and DA in mice＇s brain tissue were tested.Results 5-HT and DA in mice＇s brain tissue of Loquat Bark（in high-,mid-,and low-dose）groups,all were lower than the model group（P〈0.01）,and lower than Metoclopramide group（P〈0.05）. Conclusion The mechanism of Loquat Bark to stop Cisplatin-induced-emetic model of mouse maybe is Inhibition of 5-HT、DA secretion,or enhanced their degradation.
出处
《江西医药》
CAS
2015年第10期1015-1016,共2页
Jiangxi Medical Journal
基金
江西省卫计委中医药科研基金课题(2013A202)
