蜂巢提取物治疗变应性鼻炎疗效观察

Therapeutic Effect of Beehive Extract for Treatment of Allergic Rhinitis

【目的】观察蜂巢提取物对变应性鼻炎患者的临床疗效。【方法】将符合纳入标准的60例受试者,随机分为大剂量组和小剂量组各30例。大剂量组给予口服蜂巢提取物15 g/次,3次/d;小剂量组给予口服蜂巢提取物5 g/次,3次/d;服用1周为1个疗程,2组均服用4个疗程后观察疗效,并于停服1个月时随访。【结果】(1)大剂量组总有效率为90.00%,小剂量组为93.00%,2组比较(秩和检验),差异无统计学意义(P>0.05)。(2)治疗后及随访时,2组患者总症状视觉模拟评分量表(Uni-VAS)、鼻结膜炎生活质量量表(RQLQ)各维度评分均显著降低(P<0.01),但小剂量组患者随访时症状量表因子的分值较治疗后有所升高(P<0.05);组间比较,无论是治疗后还是随访时,2组的Uni-VAS、症状量表、非鼻/眼症状、实际问题、鼻部症状、眼部症状、情感反应等评分的下降幅度相当,差异均无统计学意义(P>0.05)。【结论】口服大剂量和小剂量蜂巢提取物均能显著改善变应性鼻炎患者的症状,两者总体疗效相当,但随访时小剂量组在症状量表评分方面有回升(即复发)的趋势。

Objective To observe the therapeutic effect of beehive extract for the treatment of allergic rhinitis.Methods Sixty qualified subjects were evenly randomized into large dose group and small dose group, 30 in each group. The large dose group was given oral use of beehive extract 15 g per time, and the small dose group was given 5 g per time, three times per day. One week constituted a treatment period, and the treatment lasted4 courses. After treatment, the therapeutic effect was evaluated in both groups. Follow-up was carried out one month after suspension of medicine. Results（ 1） The total effective rate was 90.00% in the large dose group,and was 93.00% in the small dose group, and the rank sum test results showed the difference was insignificant between the two groups（P〉0.05）.（2） After treatment and during follow-up, the scores of general symptom Visual Analog Scale（Uni-VAS） and the scores of Rhinoconjunctivitis Quality of Life Questionnaire（RQLQ）were decreased in both groups（P〈0.01）, and the scores of symptoms in the small dose group were increased during the follow-up（ P〈0.05）. The results of intergroup comparison showed that the differences of the decrease of Uni-VAS scores, symptom scores, non-nose / eye symptom scores, practical issue scores, nasal symptom scores, eye symptom scores and emotional reaction scores were insignificant between the two group s after treatment and during the follow-up（ P〉0.05）. Conclusion Oral use of large or small dose of beehive extract shows certain therapeutic effect for allergic rhinitis by obviously relieving the symptoms of patients. The effect of large dose is similar to small dose, but the long-term effect of large dose is better.