降香商品药材的质量评价

Quality Evaluation of Lignum Dalbergiae Odoriferae Medicinal Materials

【目的】对目前市场和临床使用的降香商品药材的质量进行分析和评价。【方法】按照《中华人民共和国药典》2010年版降香项下的方法,对18批降香商品药材进行性状鉴别、薄层鉴别和挥发油含量测定;建立可见分光光度法测定合格药材的总黄酮含量;建立气相色谱法测定合格药材的挥发油中橙花叔醇的含量。【结果】多批降香药材质量达不到药典标准,样品合格率仅为33.3%;合格药材的总黄酮含量在21.6~29.0 mg/g;合格药材的挥发油中橙花叔醇的含量范围是294~574 mg/g。【结论】目前市场和临床使用的降香商品药材品质参差不齐,混伪现象较严重,不同批次的样品指标成分含量差异显著。

Objective To evaluate the quality of medicinal materials of Lignum Dalbergiae Odoriferae in Chinese herbal medicine market. Methods Eighteen batches of commercial medicinal materials of Lignum Dalbergiae Odoriferae were identified and analyzed by macroscopical identification, thin layer chromatography（TLC）, and volatile oil assay according to the Chinese Pharmacopoeia published in 2010. Visible spectrometry was used to determine the content of total flavonoids from the qualified samples. And the gas chromatography was applied to evaluate the content of nerolidol from volatile oils of the qualified samples. Results Only 33.3% of the samples met the standard of Chinese Pharmacopoeia. The total flavonoid content of the qualified samples was in the range of 21.6-29.0 mg/g. The content of nerolidol from volatile oils of the qualified samples was in the range of 294-574 mg/g.Conclusion At present, the quality of medicinal materials of Lignum Dalbergiae Odoriferae in Chinese herbal medicine market and in clinic varies greatly, and adulterants and inferior are common. The contents of chemical components in different batches of samples are significant different.