非结合胆红素/白蛋白比值与脑干诱发电位相关性及对胆红素脑损伤预测价值

correlation Predictive and value between non conjugated bilirubin/albumin ratio and brain stem evoked potential in predicting bilirubin brain damage

目的 :探讨新生儿非结合胆红素/白蛋白比值与ABR相关性及对胆红素脑损伤的预测价值,为防治提供临床依据。方法:以2013年1月至2014年12月在庆阳市妇幼保健院新生儿病房收住的113例足月高胆红素血症患儿为观察对象,检查血清总胆红素、非结合胆红素水平、计算总胆红素/白蛋白(B/A)、非结合胆红素/白蛋白(UCB/A)比值,ABR,并监测其伴随疾病。结果:观察时间内,113例高胆红素血症的足月新生儿中合并胆红素脑病31例,无胆红素脑病患儿82例。分析了B/A、UCB/A及ABR诊断胆红素脑病的灵敏度、特异性及Youden指数。结论:UCB/A值与ABR对胆红素脑损伤有诊断价值,可作为目前临床检测新生儿胆红素脑损伤的方法。

Objective：To study the predictive value of neonatal bilirubin/albumin ratio with ABR correlation to bilirubin brain damage in order to provide the clinical basis for the prevention and control. Methods：113 cases of full-term neonatal hyperbilirubinemia in Qingyang maternal and child care from Jan 2013 to Dec 2014 were checked levels of the serum total bilirubin and the combination of bilirubin, calculates ratio of total bilirubin/albumin（B/A） and the combination of bilirubin/albumin（UCB/A）, ABR and its associated with disease. Results： In the observation period, there were 31 cases of bilirubin encephalopathy and no bilirubin encephalopathy of 82 cases. The sensitivity and specificity of B/A, UCB/A, ABR and Youden index in the diagnosis of neonatal hyperbilirubinemia were analyzed. Conclusion：UCB/A value and ABR have diagnostic value to the bilirubin brain damage, which can be used as a method to detect neonatal bilirubin brain injury at present.