摘要
Echinoside A is a triterpene saponin isolated from the sea cucumberActinopyga echinites （JAEGER）, which displays potent antitumor activities in vitro and in vivo. Here, we report the synthesis of the ABC-fused ring skeleton of the aglycon of Echinoside A, with the enantiomerically pure （＋）-Wieland-Miescher ketone being used as starting material and a Robinson annulation as the key reaction.
Echinoside A is a triterpene saponin isolated from the sea cucumberActinopyga echinites （JAEGER）, which displays potent antitumor activities in vitro and in vivo. Here, we report the synthesis of the ABC-fused ring skeleton of the aglycon of Echinoside A, with the enantiomerically pure （＋）-Wieland-Miescher ketone being used as starting material and a Robinson annulation as the key reaction.
基金
financially supported by the Ministry of Science and Technology of China(No.2013AA092903)
