普罗布考联合缬沙坦治疗高血压早期肾损害的研究

Study of Probucol combined with Valsartan on early renal damage caused by hypertension

目的观察普罗布考联合缬沙坦治疗高血压早期肾损害的临床疗效。方法 56例高血压早期肾损害患者随机分为对照组和治疗组,两组均予接受缬沙坦80 mg口服,每日1次,如治疗2周仍不能达到目标血压(130/80mm Hg,1 mm Hg=0.133 k Pa),则增加缬沙坦用量至160 mg,每日1次;治疗组在原有治疗基础上加服普罗布考,每次500 mg,每日2次,均连续治疗12周。治疗前后,分别测定尿微量白蛋白(MAU)、尿β2-微球蛋白(β2-MG)、血胱抑素(Cys C)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、总胆固醇(CHOL)、三酰甘油(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)。结果两组治疗后MAU、β2-MG、Cys C较治疗前显著下降(P<0.05),与对照组比较,治疗组MAU、β2-MG、Cys C下降更显著(P<0.05),MDA显著下降,SOD显著升高(P<0.05),治疗组CHOL、LDL较治疗前显著下降(P<0.05),两组治疗前后TG、HDL差异均无显著性(P值均>0.05)。结论缬沙坦有效降低高血压早期肾损害患者MAU、β2-MG、Cys C水平;普罗布考联合缬沙坦可降低氧化应激水平,更显著降低高血压早期肾损害患者MAU、β2-MG、Cys C水平,能更好地保护肾脏。

Objective： It is to observe the clinical curative effect of Probucol combined with Valsartan on early renal damage caused by hypertension. Methods： 56 patients were randomly divided into treatment group and control group and all were given Valsartan 80mg taken orally once a day. Increased 160 mg of Valsartan dosage each day if it cant reach the tar- get blood pressure （ 130/80 mmHg, 1 mmHg =0. 133 kPa）. Treatment group were given Probucol 500 mga time and twice a day for 12 weeks based on those given. The uric albumin （MAU） , urine 132 - microglo - culin （ J32 - MG） ,serum cystat- inC （ CysC ）, malondialdehyde （ MDA ）, superoxide dismutase （ SOD ）, cholesterol （ C HOL） , triglyceride （ TG ）, high - density lipoprotein（HDL） and low - density lipoprotein （LDL） were determined before and after treatment. Results： After therapy, the levels of MAU, 132 - MG and CysC of treatment were significantly lower than that of the control and before treatment, the differences were significant（ P 〈 0. 05 ） , the level of MDA of treatment were lower than that of the control and before treatment, the level of SOD of treatment were higher than that of the control and before treatment, the difference was statisti- cally significant （ P 〈 0. 05 ） , the levels of CHOL and LDL of treatment were significantly lower than that of before treat- ment,the differences were significant（P 〈 0. 05 ）,there were no signifi - cant differences in serum TG and HDL between the 2 groups before and after treatment （P 〉 0. 05 ）. Conclusion： Valsartan alone can decrease the leves of MAU,132 -MGand CysC on early renal damage caused by hypertension, the combination application of Valsartan and probucol can improve oxidative stress on early renal damage caused by hypertension, resulting in reduced serum MDA levels,improved SOD activi- ty and more decreased MAU ,β2 - MG and CysC levels, the combination of Valsartan and probucol has more renal - protec- tion effect.