前列地尔对心力衰竭患者心脏功能和心室重构影响

The Effect of Alprostadil on Cardiac Function and Ventricular Remodeling of Patients with Cardiac Failure

目的:探讨前列地尔对心力衰竭患者心脏功能和心室重构的影响。方法:将2013年8月至2015年5月广东省潮州市饶平县华侨医院心内科收治的心力衰竭患者80例随机分为对照组和研究组各40例,两组年龄、病程、原发病和心室率等差异无显著性(P>0.05);对照组按常规治疗,研究组在对照组治疗的基础上加用前列地尔10 ug/次,每日1次,持续10-14 d,2周后比较两组治疗前后心脏功能和心室重构的变化。结果:与对照组相比,治疗后研究组的左室舒张末期内径缩小,左室射血分数增高,6 min步行距离延长,静息心率显著减慢(P均<0.01);研究组总有效率高(P<0.01),且无严重并发症发生。结论:应用前列地尔治疗心力衰竭安全、有效,能明显改善心脏功能和心室重构,值得临床推广应用。

Objective：To explore the effect of alprostadil on cardiac function and ventricular remodeling of patients with cardiac failure. Method：80 patients with cardiac failure in Overseas Chinese Hospital of Raoping County were divided into research group （n=40） and control group （n=40） randomly from Aug 2013 to May 2015. The research group was treated by alprostadil based on the conventional methods in the control group. There were no differences in the baseline data including age, history, primary disease and ventricular rate between the two groups. Alprostadil was added 10 μg/d for 10-14 days in research group. The differences on cardiac function and ventricular remodeling were compared after 2 weeks after treatment between the two groups. Results：Compared with the control group,there were shorter left ventricular end diastolic diameter,larger left ventricular ejection fraction, longer walking distance in 6 minutes and slower resting heart rate,and higher the total effective rate in the research group,all P〈0.01.There were no severe side actions in the research group. Conclusion：It is effective and safe in patients with cardiac failure treated by Alprostadil. Alprostadil could increase cardiac function and improve ventricular remodeling and could be used more popular in patients with cardiac failure.