非可控性炎症与头颈恶性肿瘤的关系

Relationship between Nonresolving Inflammation and Head and Neck Cancer(HNC)

"癌症源于慢性炎症"之说越来越被人们关注与认可,已成为近年肿瘤领域研究的热点。与肿瘤密切相关的炎症实质为非可控性炎症,触发并参与肿瘤的发生、发展、浸润转移等各个病理过程;而在肿瘤发生发展过程中,肿瘤细胞同样可通过自分泌或其他方式调控非可控性炎症反应,以利于自身生长。非可控性炎症在头颈恶性肿瘤发生、进展过程中均扮演着十分重要的角色,在此过程中涉及众多分子和信号通路的参与。本文就非可控性炎症与头颈恶性肿瘤(鼻咽癌、喉癌、口腔癌、甲状腺肿瘤及皮肤肿瘤)的相互关系进行简要综述。

Recently, the topic of ＂tumors arose from chronic inflammation＂ has been paid more attention and increasingly recognized by people, which has become the hotspot in the research of tumor. In fact, the cancer- associated inflammation is nonresolving inflammation, and nonresolving inflammation is closely related to the initiation, progression, metastasis of tumor. However, tumor cells can also sustain and amplify the local inflammatory reaction directly through secreting various inflammatory mediator by autocrine or other ways, and result in promoting the survival and growth of themselves. Nonresolving inflammation has been demonstrated to participate in the initiation and progression of head and neck cancer （HNC）, in which many molecules and signaling pathways were involved. In this article, I would like to review the relationship between nonresolving inflammation and HNC （such as nasopharynx cancer, laryngocarcinoma, oral cancer, thyroid cancer and skin cancer）.