辛伐他汀治疗老年高血脂患者疗效与安全性的最佳剂量研究

Efficacy and Safety of Optimal Dose of Simvastatin for Elderly Patients with Hyperlipemia

目的:观察不同剂量辛伐他汀治疗老年高血脂患者疗效与安全性。方法:将纳入研究的80例老年高血脂患者随机分为高剂量组和低剂量组,各40例。高剂量组给予辛伐他汀剂40 mg/日,低剂量组给予20 mg/日。治疗2个月后观察疗效、血脂水平变化情况,并统计两组不良反应的发生情况。结果:高剂量组总有效率95%显著高于低剂量组的80%(P<0.05);治疗后,两组TG、TC、LDL-C、HDL-C水平均有改善,与本组治疗前比较均有显著性差异(P均<0.05),且高剂量组上述指标改善明显优于低剂量组(P均<0.05);治疗期间两组不良反应发生率无统计学意义(P>0.05)。结论:辛伐他汀高剂量(40 mg/日)治疗老年高血脂的疗效优于低剂量(20 mg/日),且不增加不良反应发生的风险。

Objective： To observe the efficacy and safety of different doses of simvastatin in the treatment of elderly patients with hyperlipemia. Methods： A total of 80 elderly patients with hyperlipemia were randomly divided into high dose group（n=40） and low dose group（n=40）. The high dose group was treated with 40 mg/d simvastatin, while the low dose group, 20 mg/d simvastatin. After 2 months of treatment, the efficacy and blood lipid levels of the two groups were observed, and the incidence of adverse reactions in the two groups was analyzed. Results： The total effective rate（95%） in the high dose group was significantly higher than that（80%） in the low dose group（P〈0.05）. Compared with before treatment, the levels of TG, TC, LDL-C, HDL-C in the two groups after treatment were significantly improved（P〈0.05）, and the above indexes in the high dose group were significantly better than those in the low dose group（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion： The efficacy of high dose of simvastatin（40mg/d） is better than that of low dose of simvastatin（20 mg/d） in the treatment of elderly patients with hyperlipemia,which does not increase the incidence of adverse reactions.