超顺磁性氧化铁在吞噬细胞标记和示踪领域的研究进展

Advancement of Superparamagnetic Iron Oxide Application in Phagocytic Cell Mark and Tracking Field

超顺磁性氧化铁(SPIO)颗粒在磁共振分子影像中发挥重要作用,SPIO可标记巨噬细胞或其它细胞从而能够追踪标记细胞在体内分布和转化,成为生物医学研究的重要部分。此外,细胞的SPIO标记及示踪可用于肿瘤及炎症诊断、评价及鉴别诊断等多方面。因此,本文汇总近年来SPIO在吞噬细胞标记和示踪领域的研究进展情况,现报道如下。

Superparamagnetic iron oxide（SPIO） plays an important role in magnetic resonance and molecule imaging. SPIO can track the vivo distribution and transformation of macrophage or other cells cell as they are marked by SPIO, which has becoming an important part of biomedical research. In addition,S PIO cell mark and tracking can be used in the diagnosis, assessment and differentiation of tumor and inflammation.Therefore, this article summarize the research progress of SPIO in phagocyte cell marker and tracking field in recent years and now report as follows.