尼麦角林注射液治疗脑血管功能不全观察

Observation on treatment of cerebrovascular insufficiency with nicergoline injection

目的探讨尼麦角林注射液治疗老年脑血管功能不全的临床效果和安全性。方法选取老年脑血管功能不全患者188例,随机分为两组,均积极治疗糖尿病、高血压、高血脂等合并疾病,对照组予尼莫地平静脉滴注,观察组予尼麦角林注射液静脉滴注,比较两组治疗效果及不良反应;采用经颅多普勒超声检测患者大脑中动脉(MCA)和椎动脉(VA)收缩期峰流速(Vs)、舒张期膜流速(Vd)、阻力指数(RI)和搏动指数(PI)治疗前后的变化。结果观察组总有效率为85.11%,显著高于对照组的58.51%(P<0.05);治疗前两组大脑中动脉和椎动脉Vs、Vd、RI及PI差异无统计学意义(P>0.05),治疗后观察组大脑中动脉Vs和Vd均明显高于对照组,大脑中动脉和椎动脉RI和PI均明显低于对照组(P<0.05);两组不良反应发生率无统计学差异(P>0.05)。结论应用尼麦角林注射液治疗老年脑血管功能不全疗效良好,安全性高。

Objective To explore the clinical curative effects and security of nicergoline injection on the treatment of senile cerebrovascular insufficiency. Methods 188 cases of senile cerebrovascular insufficiency were selected and randomly divided into two groups. The complicated diseases such as diabetes, hypertension, and hyperlipemia were actively treated. Control group received intravenous infusion with nimodipine, and observation group received intravenous infusion with nicergoline injection. The therapeutic effects and adverse reactions of the two groups were compared. Transcranial Doppler sonography was used to detect the changes in, systolic peak velocity （Vs）, diastolic flow velocity （Vd）, resistance index （RI）, and pulse index （PI） of patients＂ middle cerebral artery （MCA）, vertebral artery（VA）, before and after the treatment.Results The total effective rate of the observation group was 85.11% and was significantly higher than that of the control group （58.51%） （P 〈 0.05）. Before the treatment, the differences of Vs, Vd, RI, and PI of middle cerebral artery and vertebral artery between the two groups were not significant （P 〈 0.05）. After the treatment, the middle cerebral artery Vs and Vd in the observation group were all significantly higher than those in the control group, and the middle cerebral artery and vertebral artery RI and PI were significantly lower than those in the control group （P 〈 0.05）. The difference in the incidence of adverse reaction between the two groups was not significant （P 〉 0.05）. Conclusion The treatment of senile cerebrovascular insufficiency with nicergoline injection has good curative effects and high safty.