5-氧-烯丙基-2,3,4-三-氧-苄基-D-核糖醇的合成工艺改进

Improved synthesis of 5-allyloxy-2,3,4-tris(benzyloxy) pentan-1-ol

目的合成5-氧-烯丙基-2,3,4-三-氧-苄基-D-核糖醇。方法以D-核糖为原料,经甲苷化、苄基化、水解、肟保护、烯丙基化、脱肟、还原7步反应得到5-氧-烯丙基-2,3,4-三-氧-苄基-D-核糖醇。结果与讨论总收率55%,目标产物结构经核磁共振氢谱确认。该合成路线步骤少,绿色环保,适合工业化生产。

Objective To synthesize 5 - allyloxy - 2,3,4 - tris(benzyloxy)pentan - 1 - ol. Methods With D - ri-bose as the starting material,5 - allyloxy - 2,3,4 - tris(benzyloxy)pentan - 1 - ol was obtained by glycosidation,benzyla-tion,hydrolyzation,oxime protection,allylation,deoximation and reduction. Results and Conclusion The overall yield of this method was 55% ,and the structure of product was characterized by 1H - NMR. The synthetic route was short and envi-ronmentally friendly,suitable for the industrial production.