高压氧联合活血填精补肾汤治疗血管性痴呆疗效及对一氧化氮的影响

Efficacy of Hyperbaric Oxygen Combined with Huoxue Tianjing Bushen Decoction in Treatment of Vascular Dementia and Its Effects on NO

目的观察高压氧联合活血填精补肾汤治疗对血管性痴呆(VD)患者智能状态和生活能力及一氧化氮(NO)和一氧化氮合酶(NOS)的影响?方法将100例VD患者随机分为治疗组和对照组各50例?治疗组予高压氧联合活血填精补肾汤,对照组予高压氧联合尼莫地平片?治疗前及治疗开始后1、2、3个月采用简易智能状态量表(MMSE)及日常生活能力量表(ADL)进行评价,并测定治疗前后血中NO含量?NOS活性?结果 2组MMSE评分均于治疗前最低,治疗开始后1个月时治疗组低于对照组,2、3个月时治疗组均高于对照组(P<0.05)。2组ADL评分均于治疗前最低,治疗开始后3个月最高,2、3个月时治疗组均高于对照组(P<0.01)。2组治疗后NO、NOS均下降,且治疗组下降更明显(P<0.01)。2组均未见不良反应。结论高压氧联合活血填精补肾汤能改善VD患者智能状态及日常生活能力,其机制可能与其降低NO含量、抑制NOS活性有关。

Objective To observe the effects of hyperbaric oxygen(HBO) combined with Huoxue Tianjing Bushen Decoction on improving intelligent state and daily life ability of patients with vascular dementia(VD), and the effects on NO and NOS. Methods One hundred VD patients were randomly divided into treatment group and control group, 50 cases in each group. Patients in the treatment group were given HBO combined with Huoxue Tianjing Bushen Decoction, while patients in the control group were given HBO combined with Nimodipine for treatment. MMSE scale and ADL scale were used to evaluate the clinical efficacy before and 1, 2, 3 months of treatment. The contents of NO and NOS before and 3 months of treatment were detected. Results MMSE scores were the lowest before treatment in both groups. 1 month of treatment, MMSE scores in the treatment group were lower than those in the control group. 2 months and 3 months of treatment, MMSE scores in the treatment group were higher than those in the control group(P <0.05). The ADL scores in two groups were the lowest before treatment, and were the highest 3 months of treatment. 2 months and 3 months of treatment, ADL scores in the treatment group were higher than those in the control group(P <0.01). The contents of NO and NOS in two groups decreased after treatment, and that in the treatment group decreased more obviously(P <0.01). There was no adverse reaction in two groups. Conclusion HBO combined with Huoxue Tianjing Bushen Decoction can improve intelligent state and daily life ability of patients with VD. Its mechanism may be associated with decreasing the contents of NO and NOS.