摘要
目的观察加味参芪地黄汤在晚期前列腺癌最大限度雄激素阻断治疗中应用的临床疗效。方法将64例接受最大限度雄激素阻断治疗的晚期前列腺癌患者随机分为治疗组和对照组各32例,治疗组去势后服用比卡鲁胺胶囊和加味参芪地黄汤,对照组去势后单纯服用比卡鲁胺胶囊,治疗6个月。治疗前后检测血清前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)及睾酮(T),采用前列腺癌中医证候问卷对中医症状进行评分。结果 2组治疗后PSA、FPSA、T均显著下降(P>0.05)。治疗后治疗组尿频尿不畅、食欲不振、神疲乏力、腰酸背痛、体质量减轻、自我评价得分评分降低(P<0.05),对照组尿频尿不畅、腰酸背痛、体质量减轻评分降低(P<0.05)。2组治疗后比较,尿频尿不畅、食欲不振、神疲乏力、腰酸背痛、体质量减轻、自我评价得分评分差异有统计学意义(P<0.05)。结论加味参芪地黄汤在晚期前列腺癌最大限度雄激素阻断治疗中可以有效提高患者的生存质量,改善临床症状。
Objective To observe the clinical efficacy of modified Shenqi Dihuang Decoction in maximum androgen blockade treatment for advanced prostate cancer. Methods Totally 64 cases of patients accepting maximum androgen blockade treatment for advanced prostate cancer were randomized divided into control group and treatment group, 32 cases for each group. The treatment group was treated by modified Shenqi Dihuang Decoction combined with Bicalutamide capsule, and control group was only treated by Bicalutamide capsule for six months. Serum PSA, FPSA and T before and after treatment were detected, and TCM syndrome scores were observed through TCM syndrome questionnaire for prostate cancer. Results PSA, FPSA and T were reduced in both groups(P >0.05). After treatment, the scores of urinary frequency and dribble urination, poor appetite, lack of mental weariness, body aches, weight loss, and overall self-evaluation in the treatment group were decreased(P <0.05), and the scores of urinary frequency and dribble urination, body aches, and weight loss were decreased in the control group(P <0.05). There was a significant difference in the urinary frequency and dribble urination, poor appetite, lack of mental weariness, body aches, weight loss, and overall self-evaluation score between the two groups(P <0.05). Conclusion Modified Shenqi Dihuang Decoction can effectively promote the life quality of patients with advanced prostate cancer in the maximum androgen blockade treatment and improve clinical symptoms.
出处
《中国中医药信息杂志》
CAS
CSCD
2015年第12期26-29,共4页
Chinese Journal of Information on Traditional Chinese Medicine