黄精在抑郁症中的应用及其抗抑郁机理探讨

Discussion on Application and Anti-depression Mechanism of Polygonati Rhizoma in the Treatment of Depression

黄精治疗抑郁症具有养血补心、滋阴柔肝、健脾补中、润肺生津、补肾益精功效,以调气机之升降,解气血之郁滞。其抗抑郁作用与调节脑内单胺类神经递质水平及其受体表达、调节突触可塑性及促进神经再生、调节机体微量元素等密切相关,并涉及抗疲劳、调节免疫、抗炎、调节血糖血脂及改善心脑循环等。本文通过文献分析,结合抑郁症病机,总结其配伍应用规律及抗抑郁机理。为中医临床治疗抑郁症提供思路。

Polygonati Rhizoma has the effects of nourishing blood and tonifying heart, nourishing yin liver, tonifying spleen and strengthening the middle warmer, moistening lung and producing body liquid, nourishing kidney and strengthening the essence, with a purpose to regulate the rising and falling of qi function and treat qi-blood stasis for the treatment of depression. Its anti-depression effect is related to the regulation of monoamines neurotransmitter level in brain and the receptor expression, synaptic plasticity and promotion of nerve regeneration, and body microelement. It is also involved with resisting fatigue, immune regulation, anti inflammation, regulating blood fat and blood glucose, and improving cardio cerebral circulation. Based on depression pathogenesis, this article summarized the compatibility application laws and anti-depression mechanism through literature analysis, believed that in-depth study on the anti-depression effect of Polygonati Rhizoma will provide scientific references for TCM treatment for depression in clinic.