阿奇霉素联合红霉素治疗支原体肺炎患儿的临床疗效观察

Observation of clinical efficacy of Azithromycin combined with Erythromycin in treatment of children with mycoplasma pneumonia

目的:观察阿奇霉素联合红霉素治疗支原体肺炎患儿的临床疗效。方法:将93例支原体肺炎患儿进行随机分组,分为阿奇霉素组、红霉素组和联合组,每组各31例。阿奇霉素组患儿给予阿奇霉素进行治疗;红霉素组患儿给予红霉素进行治疗;联合组患儿给予阿奇霉素联合红霉素进行治疗。3组患儿疗程均为2周。治疗后比较3组患儿的退热时间,咳嗽消失时间,啰音消失时间等临床疗效及不良反应情况。结果:联合组与红霉素组患儿退热时间最短,明显优于阿奇霉素组;联合组与阿奇霉素组患儿的啰音消失时间明显短于红霉素组,差异均有统计学意义(P<0.05)。红霉素组患儿的治愈率为35.4%,阿奇霉素组患儿的治愈率为41.9%,联合组患儿的治愈率为64.5%,差异均有统计学意义(P<0.05)。结论:阿奇霉素联合红霉素治疗支原体肺炎患儿的临床疗效优于单纯阿奇霉素或红霉素。

Objective: To observe clinical efficacy of Azithromycin combined with Erythromycin in treatment of children with mycoplasma pneumonia. Methods: 93 cases of mycoplasma pneumonia were randomly divided into three groups,31 patients of Azithromycin group,31 cases of Erythromycin group,and 31 cases of combination group( Azithromycincombined with Erythromycin). The three groups were treated for two weeks,and then cooling time,cough disappeared time,rales disappeared time and adverse reactions of the three groups were compared. Results: Comparison of the efficacies of the three groups,the combination group and erythromycin group had the shortest cooling time than Azithromycin group,and the difference was statistically significant( P<0.05); the combination group and Azithromycin group had shorter rales disappearedtime than Erythromycin group,and the difference was statistically significant( P<0.05). The cure rates were 35.4% for Erythromycin group,41.9% for Azithromycin group,and 64.5% for combination group,and the differenceswere statistically significant( P<0.05).Conclusions: Azithromycin combined with Erythromycin in the treatment of the children with mycoplasmapneumonia has better clinical efficacy than single Azithromycin and Erythromycin.