麝香保心丸对一次性力竭运动大鼠心肌损伤标记物和C反应蛋白的影响

Influence of Shexiangbaoxinwan on myocardial injury markers and C-reactive protein after a single bout of exhaustive exercise in rats

目的探讨麝香保心丸对一次性力竭运动大鼠心肌损伤标记物和C反应蛋白的影响。方法选择雄性Wistar大鼠52只,随机分成实验组和对照组,每组26只。两组大鼠每天自由进食饮水相同,实验组大鼠每天麝香保心丸2粒(每粒22.5 mg)分2次灌胃,共两周。两组均接受力竭游泳运动,制成力竭运动动物模型,分别测定和比较两组大鼠血清和心肌组织肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(Tn T)、B型脑钠肽(BNP)和C反应蛋白(CRP)水平。结果大鼠平均力竭运动游泳时间实验组较对照组明显延长(P<0.01)。实验组血清和心肌组织CK、CK-MB、Tn T、BNP和CRP水平均明显低于对照组(P<0.05)。结论麝香保心丸可显著降低力竭运动大鼠血清和心肌中CK、CK-MB、Tn T、BNP和CRP水平,能够减轻力竭运动后心肌损伤。

Objective To observe the influence of a Chinese traditional medicine , Shexiangbaoxinwan , on myo-cardial injury markers and C-reactive protein in exhaustively exercised rats .Methods A total of 52 male 11-12 week old Wistar rats were divided randomly into two groups：the experimental （n=26） and control groups （n =26）.The two groups of rats took food and water freely .The experimental group of rats was given Shexiangbaoxinwan （ 2 capsules per day ） for two weeks.Following a single bout of exhaustive swimming （≥2 hrs）, the serum and myocardial CK , CK-MB, TnT, BNP and CRP in both groups were determined and compared .Results Compared with the control group , the exhaustive swim-ming time of the experimental group was significantly prolonged （P〈0.01）.The levels of serum and myocardial CK , CK-MB, TnT, BNP and CRP in the experimental group were significantly lower than those in the control group （ P〈0.05 for all） .Conclusions The Chinese traditional medicine Shexiangbaoxinwan can significantly decrease the levels of rat serum and myocardial CK , CK-MB, TnT, BNP and CRP after a single bout of exhaustive swimming , and car alleviate myocardial injury.