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多发性硬化实验动物模型研究进展 被引量：2

Research progress of animal models of multiple sclerosis
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摘要 实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)是多发性硬化的实验动物模型,经过近2个多世纪的发展,已可以在猴、大鼠、小鼠等动物制备EAE模型,在同一种品系动物采用不同免疫抗原制备的EAE模型在敏感性和临床特点具有多样性。本研究就EAE的发展史和目前不同品系实验动物、不同抗原制备EAE模型的特点做一述评,对未来EAE模型的发展前景进行探讨。 Experimental autoimmune encephalomyelitis （ EAE ） is a classic animal model for multiple sclerosis . After more than 2 centuries of development , EAE can be established in mice , monkeys and rats ,etc.Some animals can be immunized by different immune antigens which have different features in sensibility and clinical characteristics .In this pa-per, we will review the development of EAE , discuss the characteristics of EAE models produced by immunization of differ-ent animals with different antigens .In summary, we explore the development of animal models of EAE .
作者 李迎霞 关东升 任德启 郭健 吴川杰
机构地区 河南中医学院第二临床医学院 郑州大学第一附属医院
出处 《中国实验动物学报》 CAS CSCD 北大核心 2015年第5期535-538,共4页 Acta Laboratorium Animalis Scientia Sinica
基金 国家自然科学基金青年项目(No.81202657) 河南省中医管理局河南省中医临床学科领军人才培育计划(No.201301006) 河南省教育厅科学技术研究重点项目(No.13A360556)
关键词 多发性硬化 实验性自身免疫性脑脊髓炎 模型 动物 Multiple sclerosis Experimental autoimmune encephalomyelitis Models animal
分类号 Q95-33 [生物学—动物学]
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参考文献25

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二级参考文献8

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中国实验动物学报
2015年 第5期

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