氟西汀单用与合并认知行为治疗对围生期发生重性抑郁障碍患者疗效的对照研究

The Comparative Study of Fluoxetine Combined with Cognitive-behavioral Therapy in the Treatment of Postpartum Depression

目的研究氟西汀单用与合并认知行为治疗对围生期发生的重性抑郁障碍(PPD)患者的治疗效果和安全性。方法随机选取2013年8月至2015年8月我院门诊确诊为PPD的患者98例,按照随机数字表法,将符合标准的患者分为实验组和对照组,每组49例。对照组仅服用氟西汀治疗,实验组在对照组的基础上联合认知行为治疗,治疗8周。运用HAMD评价疗效,TESS评价氟西汀的不良反应。结果实验组的总有效率93.88%显著高于对照组71.43%(P<0.01);对照组治疗后HAMD评分(9.83±5.813)高于实验组(6.02±3.405)(P<0.05);两组药物不良反应比较无显著差异(P>0.05)。结论氟西汀联合认知行为治疗PPD的疗效显著优于单用氟西汀,并且氟西汀不良反应轻微,具有巨大的临床应用价值。

Objective To study the efficacy and safy of Fluoxetine combined Cognitive behavior therapy in the cure of PPD. Methods From August 2013 to August 2015, 98 patients in our hospital who accepted treatment were selected as the study samples. They were divided into two groups which included experimental group （n=49） and control group（n=49） by random number table method. Control group was just given Fluoxetine, however, experimental group accepted Fluoxetine combined cognitive behavior therapy ,after treatment for 8 weeks.The Hamilton depression rating scale（HAMD） and treatment emergent symptom scale （TESS） was used to evaluate clincal efficacy and adverse effect of Fluoxetine receptively. Result The total effective rate in experimental group（93.88%） was significantly higher than in the control group （71.43%）（P〈0.01）. After the treatment, the HAMD score in control group（9.83±5.813） was obviously higher than that of the experimental group （6.02±3.405）（P〈0.05）. Drug adverse reactions of two groups was no significant difference （P〉0.05）. Conclusion The efficacy of fluoxetine combined the Cognitive behavior therapy is better than only fluoxetine for PPD and adverse effect of Fluoxetine is small, therefore, it has great clincal application value.