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H5N1禽流感疫苗研究进展及免疫效果影响因素分析 被引量：5

The Reach Progress on H5N1 Avian Influenza Vaccines and Analysis on the Factors Influencing Its Immune Effects
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摘要 免疫接种在H5N1高致病性禽流感的防控中发挥了重要作用,但是影响疫苗效率的因素很多,需要进一步改进和提高。本文对当前H5N1亚型禽流感灭活疫苗、载体疫苗、减毒活疫苗的使用状况和研究进展,以及影响疫苗效率的因素(免疫持续期、疫苗的抗原匹配性、疫苗生产、佐剂、母源抗体干扰)进行了综述。 Vaccination has played an important role in the prevention and control of H5N1 highly pathogenic avian influenza（HPAI）. However there are many factors influencing the vaccine efficiency,and further improvement is needed. In this paper,we reviewed the current situation and progress on H5N1 avian influenza vaccines and the factors that influence the vaccine efficiency,including immune duration,antigenic matching,vaccine production,adjuvants and maternal antibody interference.
作者 蒋文明 陈继明
机构地区 中国动物卫生与流行病学中心
出处 《中国动物检疫》 CAS 2015年第11期61-65,共5页 China Animal Health Inspection
基金 青岛市科技计划14-2-4-105-jch
关键词 禽流感病毒 H5N1 疫苗 免疫接种 研究进展 影响因素 avian influenza virus H5N1 vaccine vaccination research progress influence factors
分类号 S852.65 [农业科学—基础兽医学]
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参考文献16

  • 1Pavlova S P, Veits J, Mettenleiter T C, et al. Live vaccination with an H5-hemagglutinin-expressing infectious laryngotrache- itis virus recombinant protects chickens against different highly pathogenic avian influenza viruses of the H5 subtype[J]. Vac- cine, 2009b, 27(37): 5085-5090.
  • 2Pose A G, Gomez J N, Sanchez A V, et al. Subunit influenza vaccine candidate based on CD154 fused to HAH5 increases the antibody titers and cellular immune response in chickens[J]. Veterinary Microbiology, 2011,152( 3/4).. 328-337.
  • 3Toro H, Tang D C, Suarez D L, et al. Protective avian influ- enza in ovo vaccination with non-replicating human adenovirus vector[J]. Vaccine, 2007, 25(15): 2886-2891.
  • 4Toro H, Tang D C, Suarez D L, et al. Protection of chick- ens against avian influenza with non-replicating adenovirus- vectored vaccine[J]. Vaccine, 2008, 26(21 ):2640-2646.
  • 5Liljebjelke K A, Petkov D I, Kapczynski D R. Mucosal vac- cination with acodon-optimized hemagglutinin gene expressed by attenuated Salmonella elicits a protective immune response in chickens against highly pathogenic avian influenza[J]. Vac-cine, 2010,28 ( 27 ): 4430-4437.
  • 6Steel J, Burmakina S V, Thomas C, et al. A combination in- ovo vaccine for avian influenza virus and Newcastle disease virus[J]. Vaccine, 2008, 26(4): 522-531.
  • 7Nang N T, Song B M, Kang Y M, et al. Live attenuated H5N1 vaccine with H9N2 internal genes protects chickens from infectionsby both Highly Pathogenic H5N 1 and H9N2 Influenza Viruses[J]. Influenza and Other Respiratory Viruses, 2012,7 (2): 120-131.
  • 8Hwang S D,Kim H S,Cho SW,et al. Single dose of oil- adjuvanted inactivated vaccine protects chickens from lethal infections of highly pathogenic H5N1 influenza virus[J]. Vac- cine, 2011,29( 11 ): 2178-2186.
  • 9Sasaki T, Kokumai N, Ohgitani T, et al. Long lasting im- munity in chickens induced bya single shot of influenza vac- cine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenzavirus[J]. Vaccine, 2009, 27(38 ).. 5174-5177.
  • 10Boltz D A, Douangngeun B, Sinthasak S, et al. Fieldassess- ment of an H5N1 inactivated vaccine in chickens and ducks in Lao PDR[J].Archives of Virology, 2009, 154(6): 939-944.

同被引文献39

  • 1薛峰,张评浒,刘晓文,唐应华,龙进学,高崧,刘秀梵.H_5亚型禽流感疫苗免疫肉鸡、水禽后抗体消长规律的研究[J].扬州大学学报（农业与生命科学版）,2005,26(2):1-3. 被引量：22
  • 2陈化兰.H5N1禽流感疫苗研究及应用[J].动物保健,2006(8):32-33. 被引量：4
  • 3Gu M, Zhao G, Zhao K, et al. Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A ( H5N 1 ) Viruses, China[J]. Emerg Infect Dis, 2013, 19 (12) : 2021-2024.
  • 4Zhao K, Gu M, Zhong L, et al. Characterization of three HSN5 and one HSN8 highly pathogenic avian influenza viruses in China[J]. Vet Microbiol, 2013, 63 (3/4) .. 351-357.
  • 5Zhong L, Zhao Q, Zhao K, et al. The antigenic drift mo- lecular basis of the HSN1 influenza viruses in a novel branch of clade 2.3.4[J] Vet Microbiol, 2014, 71 (1/2) .. 23-30.
  • 6World Health Organization/World Organisation tbr Animal Health/Food and Agriculture Organization (WHO/OIE/FAO) H5NI Evolution Working Group. Revised and updated no- menclature for highly pathogenic avian influenza A ( H5N 1 ) viruses[J]. Influenza Other Respir Viruses, 2014, 8 (3) : 384-388.
  • 7Steel J, Burmakina S V, Thomas C, et al. A combina- tion in-ovo vaccine for avian influenza virus and Newcastle disease virus[J]. Vaccine, 2008, 26 (4) : 522-531.
  • 8Hoffmann E, Stech J, Guan Y, et al. Universal primer set for the full-length amplification of all influenza A viruses[J]. Arch Virol, 2001, 146: 2275-2289.
  • 9Kaverin N V, Rudneva I A, Govorkova E A, et al. Epit- ope mapping of the hemagglutinin molecule of a highly patho- genic H5N1 influenza virus by using monoclonal antibodies[J]. JVirol, 2007, 81: 12911-12917.
  • 10Velkov T, Ong C, Baker M A, et al. The antigenic archi- tecture of the hemagglutiniq of influenza H5N1 viruses[J]. Mol Immunol, 2013, 56: 705-719.

引证文献5

二级引证文献27

中国动物检疫
2015年 第11期

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