孕妇营养过剩对子代出生体重与瘦素水平影响的观察及临床意义

Clinical Observation and Significance of Leptin Level and Offspring's Birth Weight of Excessive Weight Gain Pregnant Women

目的探讨孕妇妊娠期营养过剩与新生儿出生体重及瘦素水平之间的关系。方法选择2013年在我院分娩的孕妇,在排除研究中失访或在出现如早产、妊高征或其他异常情况的孕妇后,营养过剩组和正常组妇女最后符合条件的研究对象分别为104人和113人,比较营养过剩组与正常组孕妇血清瘦素水平、子代脐血瘦素水平及出生体重,并探讨其相关性。结果营养过剩组孕妇血清瘦素浓度及其子代脐血瘦素浓度均高于正常组(P<0.05);营养过剩组产出巨大儿的比例(13.5%)高于正常组(5.3%),P<0.05;脐带血瘦素浓度、妊娠期营养过剩与新生儿出生体重呈正相关关系(r=0.35,r=0.41,P<0.05)。结论孕妇妊娠期营养过剩对婴儿的体重和瘦素浓度有明显的影响,可能增加分娩巨大儿的风险,对孕妇自身及其子代均有不利影响。

OBJECTIVE To investigate the relationships of excessive weight gain pregnant women,leptin level and offspring＇s birth weight.METHODS It chose women who gave birth at local hospitals in Huangpu Area and divided them randomly into excessive weight gain group and control group.It compared the serum leptin level of pregnant women,the offspring＇s leptin of cord blood and birth weight,and investigated their relevance.RESULTS The serum leptin level of excessive weight gain pregnant women and the offspring＇s leptin of cord blood were both higher than control group（P〈0.05）.The fetal macrosomia birthrate of excessive weight gain group（13.5%） were higher than control group（5.3%）,P〈0.05.There were positive relationship among excessive weight gain during pregnancy;the offspring＇s leptin of cord blood and birth weight（r=0.35,r=0.41,P〈0.05）.CONCLUSION The excessive weight gain during pregnancy had evident influences on the offspring＇s leptin of cord blood and birth weight,and may increase the risk of macrosomia delivery.