肠源性5-HT与成年男性骨质疏松症的相关性

RELATION OF SERUM 5-HTDROXYTRYPTAMINE TO OSTEOPOROSIS IN ADULT MEN

目的探讨肠源性5-羟色胺（5-HT）与成年男性骨质疏松症的相关性,为骨质疏松症的诊治提供新思路。方法随机选择符合研究标准的成年男性135例为对象,记录一般临床资料,测量骨密度和肠源性5-HT含量;依据年龄分为20~49岁组、50~69岁组、70~89岁组,同时依据骨密度分为正常骨量组、骨量减少组及骨质疏松组,统计分析肠源性5-HT含量与年龄、BMI和骨密度的相关性。结果 20~49岁组、50~69岁组、70~89岁组肠源性5-HT含量分别为151.93±20.06、164.43±32.22、180.40±17.89 ng/ml,含量随着年龄的增长而升高,经BMI校正后,各年龄组比较差异有显著性（P〈0.05）;骨量正常组、骨量减少组、骨质疏松组肠源性5-HT含量分别为141.25±83.67、156.14±57.99、250.53±141.09 ng/ml,含量随着骨密度的增加而降低,各组差异有显著性（P〈0.05）。结论肠源性5-HT含量与成年男性的年龄呈正相关,而与骨密度呈负相关,可作为成年男性骨质疏松症的诊断依据和治疗靶标。

Objective To investigate the relation of serum 5-hydroxytryptamine（ 5-HT） and adult men＇s osteoporosis（ OP）,so as to provide new way for the diagnosis and treatment of osteoporosis.Methods A total of135 adult men patients were selected as research objects which came from Guangzhou General Hospital of Guangzhou Military Command from May 2011 to August 2012.General clinical data were recorded; bone mineral density（ BMD） and serum 5-HT were detected.All subjects were divided into 20 to 49 age group,50-69 age group and70-89 age group according to their ages.In addition,subjects were divided into bone mass normal group,low bone mass group and osteoporosis group according to BMD.Then the relations of serum 5-HT and age,body weight,BMI and BMD were analyzed.Results The levels of serum 5-HT in 20 to 49,50-69,and 70-89 age group were（ 151.93 ± 20.06） ng / ml,（ 164.43 ± 32.22） ng / ml,and（ 180.40 ± 17.89） ng / ml,respectively.After adjustment by body weight and BMI,the difference was statistically significant among three groups（ P〈0.05）.The 5-HT levels in all adult men objects had increasing trend with their ages.Serum levels of 5-HT in bone mass normal group,low bone mass group,osteoporosis group were（ 141.25 ± 83.67） ng / ml,（ 156.14 ± 57.99）ng / ml,and（ 250.53 ± 141.09） ng / ml,the difference was statistically significant among three groups（ P〈0.05）.Conclusion Serum 5-HT is positive correlation with adult men＇s age,while negative correlation with adult men＇s bone density.5-HT may be an indicator for diagnosis and treatment of adult men＇s osteoporosis.