葫芦脲在色谱固定相中的研究进展

Advances in cucurbituril bonded stationary phases for chromatographic separation

葫芦脲是超分子化学中继冠醚、环糊精、杯芳烃之后发展起来的又一类新型高度对称的桶状大环主体分子,是一种由多个甘脲单元组成的大环穴状配体,被誉为"第四代超分子化合物"。由于其具有特殊的分离选择性和稳定性,在超分子化学和色谱的交叉领域备受关注。本文从葫芦脲的结构特征出发,侧重概述了葫芦脲同系物及其衍生物在色谱固定相中的研究现状和进展。

Cucurbit[n]urils（CB[n ]）,a kind of host molecules of the fourth generation supramolecule followed crown ethers,cyclodextrins and calixarenes in supramolecular chemistry,are macrocyclic ligands and consist of several glycoluril units. Their special molecular recognition based on unique separation selectivity and stability have gained great interest in supramolecular chemistry and chromatography. Hereby,we give a review of research progresses of cucurbit[n]urils structural features,its homologues and derivatives and their applications in chromatographic stationary phase.