右冠状动脉发育细小的血管内皮功能评价

The Evaluation of Endothelial Function in the Patients of Right Coronary Artery Hypoplasia

目的评价具有临床症状的右冠状动脉发育细小者血管内皮功能。方法选取入院疑似为冠心病(具有心绞痛症状及ST-T改变)并行冠脉造影检查示右冠状动脉细小的患者29例、X-综合征患者21例以及健康体检者21例,比较其肱动脉血流介导的血管扩张功能(FMD)以及血中循环内皮细胞(CEC)差异。结果右冠状动脉细小患者及X-综合征患者肱动脉FMD明显低于对照组(4.46±1.27,4.60±0.73 VS 12.82±2.62),右冠状动脉细小患者FMD与X-综合征患者FMD差异无显著性;右冠状动脉细小患者及X-综合征患者CEC水平明显高于对照组(8.43±1.95,7.19±1.62 VS 4.16±0.59),右冠状动脉细小患者CEC高于X-综合征患者(P<0.05)。结论右冠状动脉细小者冠脉存在内皮功能障碍,且较X-综合征患者更为严重。

Objective To evaluate the vascular endothelial function in patients of the right coronary artery hypoplasia.Methods Twenty-nine patients suspected with the coronary heart disease （angina symptoms and ST-T change） and which the coronaiy angiography show the right coronary artery hypoplasia,21 patients with X-syndrome and 21 healthy persons were enrolled.To test and compare the flow-mediated dilation （FMD） and circulating endothelial cells （CEC）.Results FMD of the right coronary artery hypoplasia and X-syndrome pa-tients were significantly lower than that of the control group （4.46±1.27,4.60±0.73 VS 12.82±2.62）.There was no difference between the right coronary artery hypoplasia patients and X-syndrome patients in FMD （P〈0.05）.The CEC of The right coronary artery hypoplasia and X-syndrome patients were significantly higher than that of the control group （8.43±1.95,7.19±1.62 VS 4.16±0.59）,in addition,the CEC in the right coronary artery hypoplasia were slightly higher than those of the patients with X-syndrome,the difference was statistically sig-nificant （P〈0.05）.Conclusion The Coronary artery of patients with the right coronary arteries hypoplasia exist the endothelial dysfunction,even more serious than X-syndrome.