复方橘皮竹茹胶囊对化学药物性便秘的药效学实验研究

The empirical pharmacodynamics study of compound orange peel bamboo shavings formula capsules in chemical constipation

目的探讨复方橘皮竹茹胶囊对化学药物性便秘小鼠便秘的治疗作用。方法以复方橘皮竹茹胶囊高、中、低三个剂量（3．2、1．6、0．8g／kg）灌胃小鼠，观察药物对复方地芬诺酯、盐酸昂丹司琼致便秘小鼠排粪的影响。结果对于复方地芬诺酯致便秘小鼠，中剂量复方橘皮竹茹胶囊缩短排粪潜伏期（P〈0．05），增加便秘第1、3小时排粪粒数（P〈0．05），中、高剂量增加4h粪粒质量（P〈0．05）；对于盐酸昂丹司琼致便秘小鼠，中、高剂量复方橘皮竹茹胶囊缩短排粪潜伏期（P〈0．05），增加便秘第1、2、3小时小鼠排粪粒数（P〈0．05），低、中、高剂量增加4h粪粒质量（P〈0．05）。结论复方橘皮竹茹胶囊具有明显促进复方地芬诺酯、盐酸昂丹司琼致便秘小鼠的排粪作用。

Objective To explore the effect of compound orange peel bamboo shavings formula capsules on constipation by examining on chemical constipation mice. Methods Constipation was induced by oral administration of diphenoxylate and ondansetron. Mice were fed with compound orange peel bamboo shavings formula capsule at the doses of 3.2, 1.6 and 0.8 g/kg, respectively. Results The middle dose and high dose of compound orange peel bamboo shavings formula capsule shortened the start time of defecation, and increased fecal pellets number and wet weight in the diphenoxylate-induced constipated mice or the ondansetron-induced constipated mice （P 〈 0.05）. Conclusion Compound orange peel bamboo shavings formula capsule produces a laxative activity against diphenoxylate-induced constipated mice or ondansetron- induced constipated mice.