儿童诺如病毒感染69例临床特征分析

Clinical characteristics analysis of 69 children infected with norovirus

目的分析某小学一起以呕吐、腹痛为主要表现的疫情资料,总结出其临床特征,为以后年长儿类似感染提供参考。方法对69例患儿的临床症状及血液、排泄物等检查结果进行回顾性分析。结果 69患儿中腹痛62例(89.9%),呕吐57例(82.6%),腹泻16例(23.1%),发热11例(15.9%)。生化检查:白细胞计数增高40例(58.0%),中性粒细胞>75%者31例(44.9%),超敏C-反应蛋白>10 mg/L者8例(11.6%),降钙素原>0.5 ng/L者3例(4.3%),肌酸激酶同工酶增高者25例(36.2%)。50例患儿行肥达氏反应,其中17例(34%)"O"抗原1∶160,血、大便/肛拭子培养均未培养出致病菌。结论本病预后良好,临床检验指标除血白细胞及中性粒细胞在早期增高外,其他检查生化指标未见明显异常。

Objective To analyze the epidemic data with the main performance of vomiting,abdominal pain in a primary school to summarize its clinical characteristics and provide reference for similar infection of older children. Methods The clinical symptoms and test results of blood,feces of 69 children were retrospectively analyzed. Results Among the 69 cases,62 cases（ 89. 9%） with abdominal pain,57 cases（ 82. 6%） with vomiting,16 cases（ 23. 1%） with diarrhea,11 cases（ 15. 9%） with fever,40 cases（ 58. 0%） with white cell count 10 × 10^9/ L,31 cases（ 44. 9%） with neutrophil percentage 〉75%,8 cases（ 11. 6 %） with ultra-sensitive CRP 10 mg/L,25 cases（ 36. 2%） with CK-MB 〉25 U/L,3 cases（ 4. 3%） with procalcitonin 〉0. 5 ng / L. Fifty cases had the Widal reaction,and 17 cases（ 34%） with‘O＇antigen 1∶160,Blood,stool and anal swab culture did not cultivate the pathogens. Conclusion The disease prognosis is good. Except for increased leucocyte and neutrophils in early stage,other examination and biochemical indexes has no obvious abnormalities.