ALB、TBIL、TBA联合检测在肝硬化及病毒性肝炎中的诊断价值

Diagnostic value of combined detection of ALB,TBIL and TBA in liver cirrhosis and viral hepatitis

目的分析白蛋白(ALB)、总胆红素(TBIL)、胆汁酸(TBA)联合检测在肝硬化与病毒性肝炎临床诊断中的应用价值。方法选取2013年8月至2014年8月于龙岗中心医院接受治疗的80例肝硬化、病毒性肝炎患者作为研究对象,其中肝硬化38例为A组,病毒性肝炎42例为B组。同时选取40例正常健康人作为对照组,采用循环酶速率法与比色法检测三组对象血清ALB、TBA及TBIL水平,分析三者联合检测在肝硬化与病毒性肝炎中的应用价值。结果 A组血清ALB水平为(26.2±5.6)g/L,明显低于B组与对照组(P<0.05)。A组血清TBA水平为(61.3±58.3)μmol/L,TBIL水平为(75.1±91.3)μmol/L,与B组、对照组比较差异有统计学意义(P<0.05)。ALB检测,A组阳性率为94.7%,高于B组的26.2%(P<0.05)。TBA、TBIL单向检测A组阳性率均为89.5%,同样高于B组,且三项联合检测A组阳性率为68.4%,显著高于B组的2.4%,组间比较差异有统计学意义(P<0.05)。结论在肝硬化与病毒性肝炎患者的鉴别诊断中,采取ALB、TBIL、TBA三项联合检测,参考价值高,准确度高,值得推广。

Objective To analyze the application value of albumin（ ALB）,total bilirubin（ TBIL）,total bile acid（ TBA）combined detection in the clinical diagnosis of liver cirrhosis and viral hepatitis. Methods From August 2013 to August 2014,eighty patients with liver cirrhosis and viral hepatitis admitted in Loggang Central Hospital of Shenzhen were selected as the research objects,including 38 cases of liver cirrhosis as group A and 42 cases of viral hepatitis as group B. Forty cases of normal healthy people were selected as control group at the same time. The levels of serum ALB,TBA and TBIL of three groups were detected by cyclophorase rate method and colorimetric detection. The application value of combined detection in liver cirrhosis and viral hepatitis was analyzed. Results The serum level of ALB of group A was（ 26. 2 ± 5. 6） g / L,which was significantly lower than that of group B and the control group（ P〈0. 05）. The level of serum TBA of patients in group A was（ 61. 3 ± 58. 3） mol /L and TBIL level was（ 75. 1 ± 91. 3） mol / L,and there were significant differences compared with group B and the control group（ P〈0. 05）. The positive rate of ALB detection of group A was 94. 7%,which was higher than that of group B（ 26. 2%,P〈0. 05）. The positive rate of single detection of TBA,TBIL in group A was 89. 5%,which was also higher than that of the group B. And the positive rate of combined detection of group A was 68. 4%,which was significantly higher than that of group B（ 2. 4%）. The differences between the two groups were significant（ P〈0. 05）. Conclusion For the diagnosis of patients with liver cirrhosis and viral hepatitis,ALB,TBIL,TBA combined detection is of high reference value and high accuracy. So it is worthy of promotion.