六味安消片联合黛力新片治疗便秘型肠易激综合征50例

Liuwei Anxiao Tablets combined with Deanxit Tablets in the Treatment of Constipation Predominant Irritable Bowel Syndrome for 50 Cases

目的观察六味安消片联合黛力新治疗便秘型IBS疗效。方法选自我院消化内科门诊符合罗马Ⅲ诊断标准的IBS-C病例100例,随机分2组,治疗组50例,对照组50例,治疗组给予六味安消片,每次4片,每日3次,疗程4周;联合口服黛力新,每次1粒,每日2次,疗程4周。对照组只给予口服黛力新,用法同治疗组。2组病例在治疗2周,4周后均进行疗效评价和心理评分。结果治疗2周后,2组组内比较,大便性状,排便费力,腹痛腹胀等临床症状改善情况及SAS、SDS评分较治疗前均明显好转,有显著性差异(P<0.05),组间比较亦有显著性差异(P<0.05),治疗组优于对照组。治疗4周后,组间比较临床症状及SAS、SDS评分无显著性差异(P>0.05)。结论六味安消片联合黛力新治疗IBS-C能迅速有效地缓解胃肠道症状,改善抑郁焦虑等心理情绪,更易于让患者接受。

Objective To observe the effect of Liuwei Anxiao tablets combined with deanxit in the treatment of constipation predominant irritable bowel syndrome（IBS）. Methods Selecting 100 cases from Outpatient of Gastroenterology according to the Rome III criteria of IBS-C cases, they were randomly divided into treatment group of 50 cases and control group of 50 cases. The treatment group was given Liuwei Anxiao tablets, 4 tablets each time, 3 times a day, and also took orally Deanxit, one pill each time, 2 times a day. The course of treatment was 4 weeks. The control group was given oral Deanxit, and the usage was the same the treatment group. After treatment of 2weeks and 4 weeks, the curative effect and psychological score of the two groups was evaluated. Results After 2 weeks of treatment, the stool, defecation, abdominal distention, abdominal pain of the two groups and other clinical symptoms, the score of SAS and SDS were sig-nificantly improved compared with those before treatment, and there was significant difference（ P〈0.05）. There was significant difference between the two groups（ P〈0.05）, and the treatment group was superior to the control group. After 4 weeks of treatment, there was no significant difference in clinical symptoms, SDS and SAS scores between the two groups（ P〉0.05）. Conclusion Liuwei Anxiao tablets combined with Deanxit in the treatment IBS-C can quickly and effectively alleviate gastrointestinal symptoms, and improve the anxiety, depression and other psychological and emotional, and is more easily acceptable to patients.